G. T. J. Huang, I. Thesleff (eds). Wiley-Blackwell price £100.00; pp 584 ISBN

9781118279236

In recent years, major advances have been made in stem cell biology and in tissue engineering technology. As a result of this rapidly evolving niche, this text focuses on the potential use of tissue specific stem cells in bioengineering of craniofacial tissues and organs. It is an introduction to stem cells with an emphasis on their role in craniofacial development. This text is divided into three sections and contains 28 well written chapters. Filled with superb, full-colour photographs and step-by-step, illustrated procedures, this book is the definitive source on all aspects of stem cells in craniofacial development.

Stem cells have the unique ability to repair and replenish adult tissues and are now being utilised in cutting-edge medical therapies. The field of stem cell biology focuses on the full spectrum of cell behaviour from the stem cell state to the fully differentiated condition. With contributions from a coterie of renowned experts in the field of craniofacial research Stem cells in craniofacial development and regeneration should become the vade mecum of aspiring researchers, developmental biologists, tissue engineers and dentists. This comprehensive text can also be utilised effectively by oral and maxillofacial surgeons and colleagues in related fields. This edition reflects the latest trends, concepts and innovations in the field of stem cell regeneration.

The first section of the book is divided into nine chapters discussing the embryogenesis, morphogenesis and regeneration of craniofacial tissues and organs. Cranial neural crest cells, temporomandibular joint and craniofacial muscle development are high-lighted. In addition, paragraphs are devoted to understanding the formation, proliferation, migration and differentiation of neural crest cells. Various contributors explain how craniofacial anomalies occur and discuss craniosynostosis and Treacher Collins Syndrome. In order to develop therapeutic strategies for minimising or preventing craniofacial anomalies it is imperative to understand the normal events that induce neural crest cells and influence their differentiation during embryogenesis.

The authors consolidate prior knowledge of stem cells in the second section of the book where they elaborate on the concept of induced pluripotent stem cells. The third section of the book focuses on stem cell mediated craniofacial tissue bioengineering. It summarises the use of scaffolds, growth factors and stem cells in engineered tissue regeneration. Chapters reinforce periodontal bioengineering strategies including the present status and some developing trends for the future.

This text offers complete coverage of stem cells in craniofacial development and regeneration highlighted by an unparalleled collection of outstanding, full-colour photographs and highly detailed drawings that clarify procedures. This book is a welcome addition to any library and is an essential reference tool for those engaged in stem cell biology.