Research abstract
British Dental Journal , E7 (2007)
doi:10.1038/bdj.2007.47
Oral and salivary changes in patients with end stage renal disease (ESRD): a two year follow-up study
C. P. Bots1, H. S. Brand2, J. H. G. Poorterman3, B. M. van Amerongen4, M. Valentijn-Benz5, E. C. I. Veerman6, P. M. ter Wee7 and A. V. Nieuw Amerongen8
- Provides the first longitudinal study on oral health in ESRD patients.
- Increases our knowledge concerning the importance of maintained oral health investigations in patients awaiting a renal transplant.
- Salivary flow rates are only temporary suppressed and increase after renal transplantation.
- After renal transplantation xerostomia and thirst return to normal, suggesting an important contribution to quality of life.
Abstract
Objectives To compare oral health, salivary flow rate, xerostomia and thirst in end stage renal disease (ESRD) patients remaining on dialysis treatment and after renal transplantation.
Design Longitudinal observation.
Setting ESRD patients recruited from dialysis centres in Amsterdam, The Hague and Utrecht, The Netherlands.
Method At baseline and after two years, salivary flow rates, xerostomia and thirst were determined in 43 ESRD patients. The number of decayed missing filled teeth/surfaces (DMFT/DMFS) was recorded, and periodontal status assessed.
Results After renal transplantation (n = 20), the salivary flow rate increased significantly from UWS = 0.30 
0.21 ml/min to 0.44 0.29 ml/min (p <0.001) and the level of xerostomia and thirst decreased. After two years, the percentage of bleeding on probing in dialysis patients (n = 23) decreased from 29.5 25.4% to 10.3 12.3%, (p <0.05). No differences in DMFT and DMFS were observed between dialysis and renal transplant patients.
Conclusions DMFT, dental plaque, gingival bleeding and periodontal indices did not change remarkably after two years, comparing dialysis and renal transplant patients. Renal transplantation enhances salivary flow and decreases symptoms of xerostomia and thirst, and hence enhances the potential to improve the quality of life of affected individuals.
- Dentist-Epidemiologist, Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit and Universiteit van Amsterdam, Van der Boechhorststraat 7, room A-220, 1081 BT Amsterdam, The Netherlands
- Assistant Professor, Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit and Universiteit van Amsterdam, Van der Boechhorststraat 7, room A-220, 1081 BT Amsterdam, The Netherlands
- Assistant Professor, Department of Social Dentistry and Dental Health Education, Academic Centre for Dentistry Amsterdam, Vrije Universiteit and Universiteit van Amsterdam, Amsterdam, The Netherlands
- Dentist, Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit and Universiteit van Amsterdam, Amsterdam, The Netherlands
- Biochemical Research Technician, Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit and Universiteit van Amsterdam, Amsterdam, The Netherlands
- Professor, Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit and Universiteit van Amsterdam, Amsterdam, The Netherlands
- Professor, Department of Nephrology, Institute for Cardiovascular Research, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
- Professor, Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit and Universiteit van Amsterdam, Amsterdam, The Netherlands
Correspondence to: C. P. Bots1 e-mail: bots@filternet.nl
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