Summaries


British Dental Journal 186, 176 (1999)
Published online: 27 February 1999 | doi:10.1038/sj.bdj.4800056a1

Restorative Dentistry: 
Efficacy of NMAB and NMAB-urea as chemomechanical caries removal reagents

E Lynch1

  • There is a resurge of interest in chemomechanical removal caries removal systems.
  • The improved efficacy of caries removal in vitro of NMAB by addition of urea has now been confirmed.
  • The improved formulation is suitable for removing caries in deciduous teeth.
  • The dentinal floors remaining after complete caries removal are suitable for bonding with dentine adhesive


Objective

To further investigate the efficacy of N-monochloro-DL-2-aminobutyrate (NMAB) and NMAB containing 2M urea (NMAB-urea) as chemomechanical caries removal reagents in deciduous teeth using standardised lesions and limited applicator pressure.

Design

In vitro.

Method

Carious dentine was removed from standardised lesions in deciduous teeth using NMAB, NMAB-urea or isotonic saline (control); 50 lesions were studied with each reagent. The surface of the dentine remaining in cavities where complete caries removal was achieved was examined by light and scanning electron microscopy.

Main results

NMAB-urea (but not NMAB) gave significantly improved caries removal compared with saline. The dentine surfaces remaining after complete caries removal were irregular and approximately one third were bacterially contaminated.

Conclusions

The improved efficacy of NMAB by the addition of urea has been confirmed. Toxicity studies are still necessary prior to clinical use of this reagent.

Chemomechanical removal of dental caries in deciduous teeth: further studies in vitro Yip H K, Stevenson A G and Beeley J ABr Dent J1999;  186: 179–182

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Comment

This paper addresses a topical subject in which there is a resurgent interest. The NMAB chemical discussed in this paper was the main active ingredient in the Caridex system was time consuming, expensive, involved noisy and expensive equipment, and was slow; it is not available on the market today. However, extensive research show its clinical efficacy, safety, patient acceptance and compatibility with filling materials.1, 2, 3, 4 Caridex was not consistently efficacious for caries removal, used large volumes of solution, took too much time to employ, had a poor shelf-life, and needed a heated reservoir and a pump solution delivery.

As also mentioned in the paper, a new method of chemomechanical caries removal CCR has been developed called Carisolv. The major differences from Caridex are a different amino acid composition, an increased sodium hypochlorite concentration, the solution consistency (and colour) and new instruments. Despite using much greater volumes of liquid, none of the three solutions in the present study has resulted in better caries removal than Carisolv. Although addition of 2M urea improved caries removal compared with saline, urea toxicity might be a problem clinically.

Chemomechanical caries removal is particularly suited for:

  • Patients with phobias to either needles or drills
  • Patients where conservation of tooth tissue is a prime requirement
  • Patients for whom local anaesthesia is contra-indicated such as those with severe medical complications
  • Children and adolescents especially when they would require an inferior dental block
  • Older patients with root caries.

The achievement of local anaesthesia can take about 5 minutes. If this can be avoided, as is the case in about 95% of patients treated with CCR, then the increased time required for the CCR method as compared with conventional drilling, is probably not significant. As it is possible to work in several quadrants of the mouth with CCR this can further reduce potential discomfort. It is notable that patients' perception of the time taken for the caries removal is that the CCR takes a shorter time compared with drilling and this could be described as an extension of wishful thinking.

In addition there are many clinical situations which are particularly suited for the use of CCR. These include root carious lesions, open caries lesions, very deep carious lesions where we wish to attempt to avoid the creation of a traumatic exposure, secondary caries around the margins of crowns or bridges and carious lesions in deciduous teeth.

The paper also comments on the fact that the prepared cavity surface structure following CCR is very different from that seen after conventional cavity preparation when using a drill. The topography is highly irregular, as has previously been shown with the Caridex system. This may increase the surface area for bonding and thus possibly improve bond strengths to certain adhesive materials.

Work has proven that CCR significantly reduces cariogenic micro-organisms, probably due to the oxidants within the product, as well as the high pH. This antimicrobial effect may well also be significant in the management of deep carious lesions. This paper adds to our knowledge of CCR, a topic of increasing interest to both practitioners and patients.

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References

  1. Burke F M, Lynch E. Principles of chemochemical caries removal. In W M Tay, E Lynch (eds). General dental treatment. Churchill Livingstone, London, 1989; ch. 2.1.5: 1–11.
  2. Burke F M, Lynch E. Principles of chemochemical caries removal. In W M Tay, E Lynch (eds). General dental treatment. Churchill Livingstone, London, 1989; ch. 2.1.6: 1–12.
  3. Burke FM, Lynch E. Chemomechanical caries removal. J Ir Dent Assoc 1995; 41: 38–43.
  4. Burke F M, Lynch E. Effect of chemomechanical caries removal on the bond strength of glass polyalkenoate cement to dentine. J Dent 1994; 22: 283–291.
  1. Senior Lecturer and Honorary Consultant in Restorative Dentistry, Royal London Hospital

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