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Estrogen receptor-beta genetic variations and overall survival in patients with locally advanced gastric cancer

The Pharmacogenomics Journal volume 17, pages 36–41 (2017)Cite this article

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Abstract

Estrogen has been shown not only to reduce the incidence of colorectal cancer but also gastric cancer (GC). Polymorphisms in estrogen receptor β gene, ESR2, correlate with colorectal cancer survival. To better understand the role of ESR2 in GC, genomic DNA extracted from 169 Japanese patients and 172 patients from Los Angeles County (LAC) was analyzed for association of overall survival (OS) with three ESR2 polymorphisms, which are of biological significance using multivariable Cox proportional hazard regression. ESR2 rs1271572 (C>A) and rs3020443 (T>G) had univariate and multivariable associations with OS in the Japanese cohort, whereas the C allele of ESR2 rs2978381 (T>C) predicted favorable OS in the Japanese cohort but worse OS in the LAC cohort. The interaction term of the ESR2 rs2978381 and cohort group reached statistical significance. Our study provides evidence that genetic variations in ESR2 gene are significantly associated with survival in patients with locally advanced GC.

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Acknowledgements

This study was partly funded by the NIH grant P30CA14089-27S1 and Yvonne Bogdanovich. It was performed in the Sharon A Carpenter Laboratory at University of Southern California/Norris Comprehensive Cancer Center and in memory of David Donaldson. Martin D Berger received a grant from the Swiss Cancer League (BIL KLS-3334-02-2014). Stefan Stremitzer is a recipient of an Erwin Schrödinger fellowship of the Austrian Science Fund (J3501-B13).

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Authors and Affiliations

  1. Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Y Sunakawa, M D Berger, S Matsusaka, W Zhang, Y Ning, A Parekh, S Stremitzer, A Mendez, S Okazaki, T Wakatsuki & H-J Lenz

  2. Division of Medical Oncology, Department of Medicine, Showa University Northern Yokohama Hospital, Yokohama, Japan

    Y Sunakawa

  3. Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    S Cao, D Yang & A H Wu

  4. Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan

    M Azuma & W Koizumi

  5. Division of Medical Oncology, Department of Medicine, Showa University Koto Toyosu Hospital, Tokyo, Japan

    K Shimada

  6. Department of Surgery, Kitasato University School of Medicine, Sagamihara, Japan

    M Watanabe

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Correspondence to Y Sunakawa.

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Sunakawa, Y., Cao, S., Berger, M. et al. Estrogen receptor-beta genetic variations and overall survival in patients with locally advanced gastric cancer. Pharmacogenomics J 17, 36–41 (2017). https://doi.org/10.1038/tpj.2015.77

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