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Presentations and discussion

The 8th Annual Pharmacogenetics in Psychiatry Meeting Report

The Pharmacogenomics Journal volume 9, pages 358–361 (2009)Cite this article

The 8th Annual Pharmacogenetics in Psychiatry Meeting was held in New York City on 17 and 18 April 2009 with a series of panel presentations, as well as plenary lectures and a debate on the strengths and weakness of the meta-analytic approach. The following is a report of the meeting presentations.

Yvon Chagnon (Laval University, Canada) presented an association study of 17 candidate genes with obesity phenotypes in patients with schizophrenia taking antipsychotics (APs) and in controls, and association analysis of 10 genes with AP-induced weight gain. The sample comprised 247 unrelated patients with schizophrenia, who had had several years of AP treatment, and 137 controls. His literature review noted 20 genes with prior reported association in the following groups: serotonergic (HTR6, HTR2A, SLC6A4, HTR2C), adrenergic (ADRB3, ADR2A), dopaminergic (DRD4), drug transporter and metabolizing enzyme (ABCB1, CYP2D6), neurotransmitter signaling (NPYF5, BDNF, GNB3, PMCH, SNAP25), and lipid pathways (LEP, LEPR, INSIG2, SCARB1, APOA4, APOE). Of these, 17 genes were selected for association analysis using single-nucleotide polymorphisms (SNPs) (N=1–30 per gene, covering up to 5-kb 5′ and 3′), genotyped using the Illumina Bead Chip 355K (Genizon, St Laurent, Quebec). Analysis was by analysis of covariance of body mass index (BMI; kg m−2) or waist circumference (cm) by genotype, with age and sex as covariates and stratifying for the four APs used (olanzapine, clozapine, quetiapine and risperidone). BMI was categorized as follows: underweight (18.5⩽BMI<25), overweight (⩾25 and <30) and obese (⩾30). Two of the seventeen genes (SCL6A4 and SCARB1) showed significant association after adjusting for multiple testing using the unstratified phenotypes; five (HTR2A, HTR2C, ADRA2A, CYP2D6 and SNAP25) showed suggestive association on stratification by AP (P<0.05). It can be noted that some markers also showed an association with the phenotypes of interest in the controls, suggesting a common pathway.

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References

  1. Lencz T, Robinson DG, Xu K, Ekholm J, Sevy S, Gunduz-Bruce H et al. DRD2 promoter region variation predicts sustained response to antipsychotic medication in first episode schizophrenia. Am J Psychiatry 2006; 163: 529–531.

    Article  PubMed  Google Scholar 

  2. Lencz T, Lambert C, DeRosse P, Burdick KE, Moran TV, Kane JM et al. Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia. PNAS** 2007; 104: 19942–19947.

    Article  CAS  Google Scholar 

  3. Veenstra-VanderWeele J, Qaadir A, Palmer AA, Cook Jr EH, de Wit H . Association between the casein kinase 1 epsilon gene region and subjective response to D-amphetamine. Neuropsychopharmacology 2006; 31: 1056–1063.

    Article  CAS  PubMed  Google Scholar 

  4. Levran O, Londono D, O'Hara K, Nielsen DA, Peles E, Rotrosen J et al. Genetic susceptibility to heroin addiction: a candidate gene association study. Genes Brain Behav 2008; 7: 720–729.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Zhang Y, Bertolino A, Fazio L, Blasi G, Rampino A, Romano R et al. Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. Proc Natl Acad Sci USA 2007; 104: 20552–20557.

    Article  CAS  PubMed  Google Scholar 

Download references

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  1. Department of Psychiatry Research, The Zucker Hillside Hospital, 75-59 263rd Street, Glen Oaks, 11004, NY, USA

    K Aitchison, A Serretti, D Goldman, S Curran, A Drago & A K Malhotra

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Correspondence to A K Malhotra.

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Aitchison, K., Serretti, A., Goldman, D. et al. The 8th Annual Pharmacogenetics in Psychiatry Meeting Report. Pharmacogenomics J 9, 358–361 (2009). https://doi.org/10.1038/tpj.2009.47

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