Figure 3 : Correlates of acute stress.

From: The Final (Oral Ebola) Vaccine Trial on Captive Chimpanzees?

Figure 3

(A) Mean change in body mass between sedations (1 kg equals 1.4% of initial mean body mass). (B) Serum glucose and (D) WBC for ten chimpanzees in this study (red circles), six chimpanzees from previous Ebola VLP vaccine study14 (solid black circles), and 26 newly captive baboons20 (open black circles). Glucose in this study and the baboon study peaked on about the same day and exhibited similar baseline levels. Higher peak glucose in baboons is consistent with more severe stress. Chimpanzee WBC in this study peaked on Day 0 then plateaued. Chimpanzee WBC in the Ebola VLP study returned to baseline by Day 56. WBC not available for baboon study. The three orally vaccinated chimpanzees that presented voluntarily for sedation (blue circles) exhibited lower values of (C) glucose and (E) WBC than the three that did not always present voluntarily (red circles). Voluntary presenters showed significantly lower serum glucose (t test Day 7 p = 0.04, Day 14 p = 0.017) and WBC (Day 7 p = 0.039) than non-voluntary presenters.(F) Alkaline phosphatase (ALP) in this chimpanzee study and the baboon study peaked on the first sampling day then decayed at similar rates to baseline concentrations that were, in both cases, 71% of the peak value, suggesting that similar mechanisms down-regulate stress responses in the two species. Baboon values have been normalized to the peak chimpanzee concentration to illustrate this similarity. Error bars in all panels are 95% confidence intervals (i.e. 1.96 standard errors).