Table 2: Pathway enrichment analysis in metabolome profiles of the maize samples.

From: An integrated multi-omics analysis of the NK603 Roundup-tolerant GM maize reveals metabolism disturbances caused by the transformation process

 n/NESp-value
Iso vs NK603 pathways
 Amines and polyamines3/42.60.0370
 Nicotinate and nicotinamide metabolism3/42.60.0370
 Fatty acid, Dicarboxylate4/81.70.0797
 Aspartate family (OAA derived)10/271.30.0908
 TCA cycle3/61.70.1300
 Dipeptide1/170.20.1359
 Free fatty acid7/191.30.1557
 Branched Chain Amino Acids (pyruvate derived)5/131.30.1780
 Phenylpropanoids3/71.50.1914
 Photorespiration2/41.70.2192
Iso vs NK603 + R pathways
 Amino sugar and nucleotide sugar7/82.30.0007
 Serine family (phosphoglycerate derived)7/101.80.0062
 Dipeptide10/171.50.0096
 TCA cycle4/61.70.0532
 Branched Chain Amino Acids (pyruvate derived)7/131.40.0536
 Aspartate family (OAA derived)12/271.20.0730
 Benzenoids2/22.60.0769
 Phenylpropanoids4/71.50.0978
 Glycolysis3/51.60.1342
 Inositol metabolism2/31.70.1885
NK603 vs NK603 + R pathways
 Phenylpropanoids3/74.30.0180
 Amino sugar and nucleotide sugar3/83.80.0271
 Fatty acid conjugate1/110.10.0899
 Branched Chain Amino Acids (pyruvate derived)3/132.30.1012
 Choline metabolism1/25.10.1719
 gamma-glutamyl2/102.00.2238
 Serine family (phosphoglycerate derived)2/102.00.2238
 Fatty acid amide1/33.40.2467
 Nicotinate and nicotinamide metabolism1/42.50.3150
 Glycolysis1/52.00.3773
  1. The 10 most altered pathways (ranked by p-values) are presented. The number of metabolites disturbed in each pathway (n) is compared to the total number of metabolites measured for the given pathway (N). Enrichment scores (ES) for each pathway are calculated as follow: ES = (number of significant metabolites in pathway/total number of detected metabolites in pathway)/(total number of significant metabolites/total number of detected metabolites). The p-values were calculated according to a one sided Fisher exact test.