Figure 2 : The number of TMA biopsies needed for estimating lymphocytic infiltrate varies among breast cancer subtypes.

From: Biopsy variability of lymphocytic infiltration in breast cancer subtypes and the ImmunoSkew score

Figure 2

(A) Correlation between core-based and tumour-based scores of lymphocyte ratio over increasing number of cores for each subtype individually and combined. A magnified view of the same plot (n = 2–5) is inset for better visualisation. Difference in subtype specific correlation between HER2 and other subtypes is statistically significant (n = 4: HER2 versus Luminal A p = 0.010; HER2 versus Luminal B p = 0.010; HER2 versus Basal p = 0.011; one-sided paired t-test). (B) Boxplot to show the total number of virtual TMA cores for tumours in each subtype. The horizontal dash line marked the median value for HER2 subtype. (C) AUC curves for taking increasing amount of TMA cores for all unselected tumours. (D) AUC curves for taking increasing amount of TMA cores for HER2 tumours.