In this Article the legend for Figure 5 is incomplete.
“Ca2+ in cytosol was measured using Fura-2 and Ca2+ in ER was measured using FRET-based probe D1ER cameleon in the basal state and after thapsigargin stimulation (100 nM for 1000 sec). Representative Ca2+ measurements in cytosol and ER (left panel). Quantitative ER Ca2+ levels of the average value prior to thapsigargin stimulation (Basal) and the minimum value after addition of thapsigargin (Tg(+)) (right panel). Data are means ± SEM, n = 43 for control, n = 50 for IRS1KO, and n = 40 for IRS2KO β-cells. *P < 0.05, **P < 0.01”.
Should read:
“(a) Ca2+ in cytosol was measured using Fura-2 and Ca2+ in ER was measured using FRET-based probe D1ER cameleon in the basal state and after thapsigargin stimulation (100 nM for 1000 sec). Representative Ca2+ measurements in cytosol and ER (left panel). Quantitative ER Ca2+ levels of the average value prior to thapsigargin stimulation (Basal) and the minimum value after addition of thapsigargin (Tg(+)) (right panel). Data are means ± SEM, n = 43 for control, n = 50 for IRS1KO, and n = 40 for IRS2KO β-cells. *P < 0.05, **P < 0.01. (b) Immunoblot of SERCA2 and β-actin in control β-cells, IRS1KO β-cells, and IRS2KO β-cells incubated with vehicle or thapsigargin (100 nM) for 8 h. Data are means ± SEM, n = 4. *P < 0.05”.
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The online version of the original article can be found at 10.1038/srep28177
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Takatani, T., Shirakawa, J., Roe, M. et al. Correction: Corrigendum: IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation. Sci Rep 6, 34969 (2016). https://doi.org/10.1038/srep34969
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DOI: https://doi.org/10.1038/srep34969
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