Table 4: Effect of efflux pump inhibitors (EPIs) on the antibiotic susceptibility levels.

From: Development and characterisation of highly antibiotic resistant Bartonella bacilliformis mutants

Table 4: Effect of efflux pump inhibitors (EPIs) on the antibiotic susceptibility levels.
MutantAntibiotic Susceptibility level in presence of EPIs
Mutant1PAβNART
disc2MIC3discMICdiscMIC
57.18Azm-35AZM0>25624>2562048
57.18Chl-40CHL184401481.5
57.18Cip-35CIP0>320>320>32
57.18Rif-35RIF0>2560>2560>256
57.19Azm-35AZM0>2560>2560>256
57.19Chl-35CHL0>2560>2560>256
57.19Cip-35CIP0>320>320>32
57.19Rif-35RIF0>2560>256096
57.20Azm-35AZM0>2560>25620>256
57.20Chl-40CHL0>2560>2560>256
57.20Cip-35CIP0>320>3220>32
57.20Rif-35RIF0>2560>25626>256
  1. ART: Artesunate; AZM: azithromycin; CHL: Chloramphenicol; CIP: Ciprofloxacin; RIF: Rifampicin. The samples in which the effect of EPIs was visible highlighted in bold.
  2. 1Antibiotic susceptibility of mutant isolates at last selection passage.
  3. 2Disc halo diameter measured in mm.
  4. 3Minimal inhibitory concentration by E.-test in mg/L.