Table 2: MICs and mechanisms of resistance.

From: Development and characterisation of highly antibiotic resistant Bartonella bacilliformis mutants

Table 2: MICs and mechanisms of resistance.
Strain Mechanisms of Resistance
MIC1 (mg/L)FluoroquinolonesMacrolidesMacr + Amph2RifamycinsEPIs3
AZMCHLCIPRIFGyrAGyrBParCParEL4L2223S rRNARpoBPAβN4ART5
57.180.190.380.5<0.016wtwtWtwtwtwtwtwt
57.18Azm-35>25620.75<0.016Δ62–65wtwtYY
57.18Azm-5St>256Δ62–65wtwt
57.18Chl-40<0.01640.38<0.016wtYY
57.18Chl-5St0.125wt
57.18Cip-35<0.0160125>32<0.016Val91wtWtwtNN
57.18Cip-5St>32Val91wtWtwt
57.18Rif-35<0.0160.750.38>256   Arg527NN
57.18Rif-5St>256   Arg527
57.19<0.0160.1250.380.016wtwtWtwtwtwtwtwt
57.19Azm-35>2560.50.125<0.016Arg70wtwtNN
57.19Azm-5St0.5Arg70wtwt
57.19Azm-5St-WH32---Arg70+Tyr74wtwt  
57.19Chl-35<0.016>2560.125<0.016A2372NN
57.19Chl-5St0.094wt
57.19Cip-350.0640.5>32<0.016wtLys475WtwtNN
57.19Cip-5St1.5wtLys475Wtwt
57.19Rif-35<0.0160.752>256Tyr540NY
57.19Rif-5St>256Tyr540
57.200.0640.250.38<0.016wtwtWtwtwtwtwtwt
57.20Azm-35>2560.381<0.016Lys6683::VSEAHVGKSNY
57.20Azm-5St2Lys66*83::VSEAHVGKS
57.20Chl-40<0.016>2560.25<0.016A2372*NN
57.20Chl-5St0.5wt
57.20Cip-350.0940.25>32<0.016Gly95wtWtwtNY
57.20Cip-5St0.38Gly95*wtWtwt
57.20Cip-5St-WH>32Gly95wtWtwt  
57.20Rif-350.09410.047>256Phe545+Tyr588NY
57.20Rif-5St>256Phe545 + Tyr588
  1. AZM: azithromycin; CHL: Chloramphenicol; CIP: Ciprofloxacin; RIF: Rifampicin.
  2. The asterisks indicate the presence of double peaks, suggesting either the presence of a double bacterial population or the presence of mutations in one of the two copies of the B. bacilliformis gene.
  3. Mutants in which cross-resistance to other antibiotics were observed are in underlined font.
  4. The final MIC of the antibiotic used in the mutant selection is shown in bold.
  5. 1Minimal Inhibitory Concentration.
  6. 2Macrolides and Amphenicols.
  7. 3Efflux Pumps Inhibitors.
  8. 4Phe-Arg-β-Naphtylamide.
  9. 5Artesunate.