Abstract
We assessed the effect of a new alpha-blocking agent, Urapidil, on neuropathic voiding dysfunction, by urodynamic studies. The residual urine volume and rate significantly decreased, whereas the average and the maximum flow rate did not increase significantly. The pressure at maximum flow and minimum urethral resistance decreased significantly. These results suggest that improvement of the voiding dysfunction in some cases could be due to the decreased micturition pressure without increasing the flow rate. The urethral resistance calculated from the pressure/flow data seemed to be a valuable index in evaluating the effects of the drug on neuropathic voiding dysfunction.
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Edvardsen P, Setekleiv J (1968) Distribution of adrenergic receptors in the urinary bladder of cats, rabbits and guinea-pigs. Acta pharmacol Toxicol 26: 437–445.
Khanna O P (1976) Disorders of micturition. Neuropharmacologic basis and results of drug therapy. Urology 8: 316–328.
Caine M (1986) The present role of alpha-adrenergic blockers in the treatment of benign prostatic hypertrophy. J Urol 136: 1–4.
Kirby R S, Coppinger S W C, Corcoran M O, Chapple C R, Flannigan M, Milroy E J G (1987) Prazosin in the treatment of prostatic obstruction. A placebo-controlled study. Br J Urol 60: 136–142.
Whitfield H N, Doyle P T, Mayo M E, Poopalasingham N (1976) The effect of adrenergic blocking drugs on outflow resistance. Br J Urol 47: 823–827.
Lenaghan D (1970) The diagnosis of prostatic obstruction by measurement of urethral resistance to flow. J Urol 103: 320–326.
Kleeman F J (1970) The physiology of the internal urinary sphincter. J Urol 104: 549–554.
Gerstenberg T, Blaabjerg J, Nielsen M L, Clausen S (1980) Phenoxybenzamine reduces bladder outlet obstruction in benign prostatic hyperplasia. A urodynamic investigation. Invest Urol 18: 29–32.
Krane R J, Olsson C A (1973) Phenoxybenzamine in neurogenic bladder dysfunction. II. Clinical considerations. J Urol 110: 653–656.
Jensen J r D (1981) Uninhibited neurogenic bladder treated with prazosin. Scand J Urol Nephrol 15: 229–233.
Cramer P, Neveux E, Régnier F, Depassio J, Bérard, E (1989) Bladder-neck opening test in spinal cord injury patients using a new i.v. alpha-blocking agent, alfuzosin. Paraplegia 27: 119–124.
Yasuda K, Nagashima K, Murayama N, Yamanishi T, Tojo M, Shimazaki J (1991) Changes of external urethral sphincter function in prostatic patients. Urol Int (Suppl) 47: 43–47.
International Continence Society Committe on Standardization of Terminolog y (1988) The standardization of terminology of lower urinary tract function. Scand J Urol Nephrol (Suppl) 114: 5–19.
Schäfer W (1985) Urethral resistance? Urodynamic concepts of physiological and pathological bladder outlet function during voiding. Neurourol Urodyn 4: 161–201.
Iverson P, Jensen K M E, Bruskewitz R C, Madsen P O (1983) Modified J nephrostomy for intravesical pressure measurement in urodynamics. Urology 11: 550–552.
Yamanishi T, Yasuda K, Murayama N, Nagashima K, Tojo M, Wada T et al 1991 Clinical effects of moxisylyte hydrochloride on micturition disturbance due to neurogenic bladder. Nishinihon J Urol 53: 283–289.
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Yamanishi, T., Yasuda, K., Tojo, M. et al. Improvement of urethral resistance after the administration of an alpha-adrenoceptor blocking agent, urapidil, for neuropathic voiding dysfunction. Spinal Cord 32, 271–276 (1994). https://doi.org/10.1038/sc.1994.47
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DOI: https://doi.org/10.1038/sc.1994.47