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Cancer Immunotherapy

Tracking early response to immunotherapy

Nature Cancer volume 1, pages 160–162 (2020)Cite this article

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Identifying indicators of response to immunotherapy is key for treatment decisions. Two studies now report that early changes in T cell repertoires and CD8+ memory effector cytotoxic T cells in peripheral blood correlate with response to immune-checkpoint inhibitors in metastatic melanoma and may serve as actionable biomarkers of immune activation.

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Fig. 1: Early T cell assessment during melanoma immunotherapy.

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Authors and Affiliations

  1. Department of Surgery, Massachusetts General Hospital, Boston, MA, USA

    Genevieve M. Boland

  2. Department of Medicine, Harvard Medical School, Boston, MA, USA

    Keith T. Flaherty

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  1. Genevieve M. Boland
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  2. Keith T. Flaherty
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Correspondence to Genevieve M. Boland.

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The authors declare no competing interests.

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Boland, G.M., Flaherty, K.T. Tracking early response to immunotherapy. Nat Cancer 1, 160–162 (2020). https://doi.org/10.1038/s43018-020-0032-8

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