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A comprehensive metabolic map for production of bio-based chemicals

Nature Catalysis volume 2, pages 18–33 (2019)Cite this article

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An Author Correction to this article was published on 10 September 2019

This article has been updated

Abstract

Production of industrial chemicals using renewable biomass feedstock is becoming increasingly important to address limited fossil resources, climate change and other environmental problems. To develop high-performance microbial cell factories, equivalent to chemical plants, microorganisms undergo systematic metabolic engineering to efficiently convert biomass-derived carbon sources into target chemicals. Over the past two decades, many engineered microorganisms capable of producing natural and non-natural chemicals have been developed. This Review details the current status of representative industrial chemicals that are produced through biological and/or chemical reactions. We present a comprehensive bio-based chemicals map that highlights the strategies and pathways of single or multiple biological reactions, chemical reactions and combinations thereof towards production of particular chemicals of interest. Future challenges are also discussed to enable production of even more diverse chemicals and more efficient production of chemicals from renewable feedstocks.

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Fig. 1: Industrial chemicals and materials produced using both biological and chemical methods.
Fig. 2: Industrial chemicals and materials produced using only biological reactions.
Fig. 3: Novel biosynthetic pathways by retrobiosynthesis and enzyme engineering.
Fig. 4: Production processes using biological and/or chemical reactions.

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Change history

  • 10 September 2019

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Acknowledgements

This work was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries (NRF-2012M1A2A2026556 and NRF-2012M1A2A2026557) from the Ministry of Science and ICT through the National Research Foundation of Korea.

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  1. Yu-Sin Jang

    Present address: Institute of Agriculture and Life Science, Division of Applied Life Science, Gyeongsang National University, Jinju, Republic of Korea

Authors and Affiliations

  1. Metabolic and Biomolecular Engineering National Research Laboratory, SMESH Laboratory, Department of Chemical and Biomolecular Engineering, Institute for the BioCentury, KAIST, Daejeon, Republic of Korea

    Sang Yup Lee, Tong Un Chae, Jae Sung Cho, Je Woong Kim, Jae Ho Shin, Dong In Kim, Yoo-Sung Ko, Woo Dae Jang & Yu-Sin Jang

  2. BioProcess Engineering Research Center, KAIST, Daejeon, Republic of Korea

    Sang Yup Lee, Hyun Uk Kim, Tong Un Chae, Jae Sung Cho, Je Woong Kim, Jae Ho Shin & Yoo-Sung Ko

  3. BioInformatics Research Center, KAIST, Daejeon, Republic of Korea

    Sang Yup Lee, Hyun Uk Kim, Dong In Kim & Woo Dae Jang

  4. Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark

    Sang Yup Lee

  5. Systems Biology and Medicine Laboratory, SMESH Laboratory, Department of Chemical and Biomolecular Engineering, KAIST, Daejeon, Republic of Korea

    Hyun Uk Kim

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S.Y.L. conceived the project and designed the study. All authors analysed literature, compiled data, planned the content and wrote the manuscript.

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Supplementary Information

Supplementary Data 1

Bio-based chemicals map in poster format

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Supplementary Note 1–2, Supplementary Figure 1, Supplementary Tables 1–3, Supplementary References

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Lee, S.Y., Kim, H.U., Chae, T.U. et al. A comprehensive metabolic map for production of bio-based chemicals. Nat Catal 2, 18–33 (2019). https://doi.org/10.1038/s41929-018-0212-4

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