Cell Rep. 24, 2392–2403 (2018).

Dietary modification as a method to improve lifespan and/or healthspan is an area of much interest. While there is a significant body of literature establishing caloric restriction as one method to increase longevity, much less information is available on other strategies. In Cell Reports, a new study describes a methionine restricted diet that extends lifespan in not only wildtype mice, but also in a mouse model of Hutchinson-Gilford Progeria Syndrome; a disease resembling premature aging. Transcriptomic analysis of hepatic tissues from both genotypes revealed significant down regulation of inflammatory pathways with methionine restriction, with changes also present in DNA repair. Lipid profiles changed as well between the control and methionine restricted diet. Moreover, addition of cholic acid to the diet improved lifespan and healthspan in the progeria mouse model.