Elife https://doi.org/10.1101/250100 (2018).

Caloric restriction is one of the few known ways by which to extend life in rodents. This effect is mediated in part by the mechanistic target of rapamycin complex 1 (mTORC1) pathway. A component of this cascade is the transcription factor C/EBPβ-LIP, one of three proteoforms translated from the cognate mRNA. As mice age, this protein increases and is associated with many of the physiological changes of aging. Using genetic methods, investigators demonstrated that decreasing levels of this protein extended lifespan in female mice; sorry guys. Several age-related phenotypes, including cancer frequency and muscle loss, were also improved. All without having to say, ‘No more pie, thank you’.