Correction to: Scientific Reports https://doi.org/10.1038/srep42212, published online 07 February 2017
This Article contains typographical errors. In the Introduction section,
“Although the direct administration of biological factors to injury sites is frequently applied, such an approach often does not lead to robust tissue regeneration and reformation due to the rapid biological clearance of these agents from our bodies1,2,3,4. Given this limitation, biodegradable scaffolds are increasingly employed as temporary frameworks for sustained delivery of biomolecules and to support neo-tissue formation.”
should read:
“Although the direct administration of biological factors to injury sites is frequently applied, such an approach often does not lead to robust tissue regeneration and reformation due to the degradation and rapid biological clearance of these agents from our bodies1,2,3. Given this limitation, biodegradable scaffolds are increasingly employed as temporary frameworks for sustained delivery of biomolecules and to support neo-tissue formation4.”
“On the other hand, miR-222 is enriched in axons and participates in controlling local protein synthesis at distal axons36-38. Such controlled local protein synthesis plays crticial roles in allowing severed axons to undergo regeneration within hours after injuries, independent of protein transport from the cell soma of neurons36,39. Unfortunately, the expression of miR-222 is often significantly altered after nerve injuries40-46. In vitro, when miR-222 was deliberately over-expressed in injured adult neurons, enhanced regrowth was observed40,41,47,48.”
should read:
“On the other hand, miR-22241 is one of the miRs that is enriched in axons and participates in controlling local protein synthesis at distal axons36-38,41. Such controlled local protein synthesis plays crticial roles in allowing severed axons to undergo regeneration within hours after injuries, independent of protein transport from the cell soma of neurons36,39. Unfortunately, the expression of these miRs40–46, and in particular, miR-22241 is often significantly altered after nerve injuries. In vitro, when miR-222 was deliberately over-expressed in injured adult neurons, enhanced regrowth was observed41.”
In the Materials and Methods section, under subheading ‘Aligned PCLEEP fibers’,
“The PCLEEP copolymer (Mw = 59,102, Mn = 25,542) was synthesized by previously reported methods43,50.”
should read:
“The PCLEEP copolymer (Mw = 59,102, Mn = 25,542) was synthesized by previously reported methods50.”
In the Results and Discussion section,
“Among the scaffolds analyzed, hydrogels8,14,52,53,54,55,56,57,58 and self-assembled peptide nanofibers59,60 are most popular.”
should read:
“Among the scaffolds analyzed, hydrogels7,8,14,52,55,56,57,58 and self-assembled peptide nanofibers9,10 are most popular.”
“Similarly, the fibrin scaffold by Taylor et al. could only deliver NT-3 for 2 weeks post-implantation due to the rapid scaffold degradation rate63.”
should read:
“Similarly, the fibrin scaffold by Taylor et al. could only deliver NT-3 for 2 weeks post-implantation due to the rapid scaffold degradation rate55.”
“Such controlled local protein synthesis at distal axons has allowed severed axons to undergo regeneration within hours after injuries35,45. This local protein synthesis is finely controlled by microRNAs, such as miR-222. Indeed, miR-222 enhanced axonal regrowth in injured adult neurons in vitro40,41,47,48.”
should read:
“Such controlled local protein synthesis at distal axons has allowed severed axons to undergo regeneration within hours after injuries36,39. This local protein synthesis is finely controlled by microRNAs40,41,47,48, such as miR-22241. Indeed, miR-222 enhanced axonal regrowth in injured adult neurons in vitro41.”
“To replenish this OL pool, oligodendrocyte precursor cells (OPCs) proliferate and are recruited to the lesion site for differentiation and remyelination74,75.”
should read:
“To replenish this OL pool, oligodendrocyte precursor cells (OPCs) proliferate and are recruited to the lesion site for differentiation and remyelination74.”
In the References section, reference 50 was incorrectly given as:
Xiao, C.-S., Wang, Y.-C., Du, J.-Z., Chen, X.-S. & Wang, J. Kinetics and Mechanism of 2-Ethoxy-2-oxo-1,3,2-dioxaphospholane Polymerization Initiated by Stannous Octoate. Macromolecules 39, 6825–6831, doi: 10.1021/ma0615396 (2006).
The correct reference is listed below as reference 1.
In addition, references 54, 59, 60 and 63 are duplicates of references 7, 9, 10 and 55 respectively.
Reference
Wang, Y.-C., Li, Y., Yang, X.-Z., Yuan, Y.-Y., Yan, L.-F. & Wang, J. Tunable Thermosensitivity of Biodegradable Polymer Micelles of Poly(ε-caprolactone) and Polyphosphoester Block Copolymers. Macromolecules 42(8), 3026–3032, https://doi.org/10.1021/ma900288t (2009).
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Nguyen, L.H., Gao, M., Lin, J. et al. Author Correction: Three-dimensional aligned nanofibers-hydrogel scaffold for controlled non-viral drug/gene delivery to direct axon regeneration in spinal cord injury treatment. Sci Rep 8, 13057 (2018). https://doi.org/10.1038/s41598-018-31314-8
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DOI: https://doi.org/10.1038/s41598-018-31314-8
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