Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

NONCODING RNA

Turning the table on miRNAs

Nature Structural & Molecular Biology volume 25, pages 195–197 (2018)Cite this article

Subjects

Transcripts with highly complementary sequences can target microRNAs (miRNAs) for degradation, but the physiological relevance of target-directed miRNA degradation (TDMD) has remained unclear. Bitetti et al. now identify a conserved vertebrate RNA that induces TDMD in the cerebellum of zebrafish and mouse to promote wild-type animal behaviors.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Target features determine distinct outcomes of miRNA binding.

Kim Caesar/Springer Nature

Fig. 2: miR-29b TDMD as a conserved function of libra lincRNA and Nrep mRNA that modulates behaviors.

Kim Caesar/Springer Nature

Fig. 3: Control and diversification of miRNA expression patterns through TDMD.

Kim Caesar/Springer Nature

References

  1. Ameres, S. L. et al. Science 328, 1534–1539 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Cazalla, D., Yario, T. & Steitz, J. A. Science 328, 1563–1566 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Libri, V. et al. Proc. Natl .Acad. Sci. USA 109, 279–284 (2012).

    Article  CAS  PubMed  Google Scholar 

  4. Marcinowski, L. et al. PLoS Pathog. 8, e1002510 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Bitetti, A. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-018-0032-x (2018).

    PubMed  Google Scholar 

  6. Taylor, G. A. et al. Genes Brain Behav. 7, 786–795 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Hausser, J. et al. Mol. Syst. Biol. 9, 711 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Bartel, D. P. Cell 136, 215–233 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Moore, M. J. et al. Nat. Commun. 6, 8864 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Broughton, J. P., Lovci, M. T., Huang, J. L., Yeo, G. W. & Pasquinelli, A. E. Mol. Cell 64, 320–333 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. de la Mata, M. et al. EMBO Rep. 16, 500–511 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Kopp, F. & Mendell, J. T. Cell 172, 393–407 (2018).

    Article  CAS  PubMed  Google Scholar 

  13. Rüegger, S. & Großhans, H. Trends Biochem. Sci. 37, 436–446 (2012).

    Article  PubMed  Google Scholar 

  14. Marzi, M. J. et al. Genome Res. 26, 554–565 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Haas, G. et al. Nucleic Acids Res 44, 2873–2887 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  16. Helwak, A., Kudla, G., Dudnakova, T. & Tollervey, D. Cell 153, 654–665 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Buenos Aires, Argentina

    Manuel de la Mata

  2. CONICET-Universidad de Buenos Aires, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Ciudad Universitaria, Buenos Aires, Argentina

    Manuel de la Mata

  3. Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland

    Helge Großhans

  4. University of Basel, Basel, Switzerland

    Helge Großhans

Authors
  1. Manuel de la Mata
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Helge Großhans
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Manuel de la Mata or Helge Großhans.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

de la Mata, M., Großhans, H. Turning the table on miRNAs. Nat Struct Mol Biol 25, 195–197 (2018). https://doi.org/10.1038/s41594-018-0040-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41594-018-0040-x

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing