In 2008, Vyazovskiy et al. published a seminal study demonstrating that sleep induces a widespread downscaling of synapses that counters the synaptic upscaling that occurred during prior wakefulness. The study laid the groundwork for current research into the ‘where’ and ‘when’ of homeostatic neuronal network regulation during sleep.
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Niethard, N., Born, J. Back to baseline: sleep recalibrates synapses. Nat Neurosci 22, 149–151 (2019). https://doi.org/10.1038/s41593-018-0327-6
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DOI: https://doi.org/10.1038/s41593-018-0327-6
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