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NEURODEGENERATIVE DISEASE

TDP-43 shapeshifts to encipher FTD severity

Nature Neuroscience volume 22, pages 3–5 (2019)Cite this article

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TDP-43 forms cytoplasmic aggregates in degenerating neurons of frontotemporal dementia (FTD) patients. Laferrière et al. now establish that TDP-43 assemblies from distinct FTD subtypes have different structures, neurotoxicities, and seeding activities, which correlate with FTD severity. Thus, distinct pathological TDP-43 assemblies akin to prion strains might underpin distinct FTD subtypes.

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Fig. 1: SarkoSpin enables isolation of distinct pathological TDP-43 assemblies from FTLD subtypes that capture disease subtype heterogeneity.

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  1. Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

    Edward M. Barbieri & James Shorter

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  1. Edward M. Barbieri
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  2. James Shorter
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Correspondence to James Shorter.

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Barbieri, E.M., Shorter, J. TDP-43 shapeshifts to encipher FTD severity. Nat Neurosci 22, 3–5 (2019). https://doi.org/10.1038/s41593-018-0299-6

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