Compromised compartmentalization of nucleus and cytoplasm has emerged as a central feature of aging and neurodegenerative diseases. Nucleocytoplasmic transport is disrupted, with widespread mislocalization of nuclear pore proteins, in TDP-43 proteinopathies such as, amyotrophic lateral sclerosis and frontotemporal dementia.
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Li, N., Lagier-Tourenne, C. Nuclear pores: the gate to neurodegeneration. Nat Neurosci 21, 156–158 (2018). https://doi.org/10.1038/s41593-017-0066-0
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DOI: https://doi.org/10.1038/s41593-017-0066-0
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