Brief Communication

Hexadirectional coding of visual space in human entorhinal cortex

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Abstract

Entorhinal grid cells map the local environment, but their involvement beyond spatial navigation remains elusive. We examined human functional MRI responses during a highly controlled visual tracking task and show that entorhinal cortex exhibited a sixfold rotationally symmetric signal encoding gaze direction. Our results provide evidence for a grid-like entorhinal code for visual space and suggest a more general role of the entorhinal grid system in coding information along continuous dimensions.

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Acknowledgements

Our research is funded by the Netherlands Organisation for Scientific Research (NWO-Vidi 452-12-009; NWO-Gravitation 024-001-006; NWO-MaGW 406-14-114; NWO-MaGW 406-15-291), the Kavli Foundation, the Centre of Excellence scheme of the Research Council of Norway – Centre for Biology of Memory and Centre for Neural Computation, The Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, the National Infrastructure scheme of the Research Council of Norway – NORBRAIN, and the European Research Council (ERC-StG RECONTEXT 261177; ERC-CoG GEOCOG 724836).

Author information

Affiliations

  1. Kavli Institute for Systems Neuroscience, Centre for Neural Computation, The Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, NTNU, Norwegian University of Science and Technology, Trondheim, Norway

    • Matthias Nau
    • , Tobias Navarro Schröder
    • , Jacob L. S. Bellmund
    •  & Christian F. Doeller
  2. Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands

    • Matthias Nau
    • , Tobias Navarro Schröder
    • , Jacob L. S. Bellmund
    •  & Christian F. Doeller
  3. St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway

    • Christian F. Doeller

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Contributions

M.N., T.N.S., J.L.S.B. and C.F.D. designed the study; M.N. ran the experiments and analyzed the data; M.N. and C.F.D. wrote the manuscript; and all authors discussed the results and revised the manuscript.

Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Matthias Nau or Christian F. Doeller.

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