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Human entorhinal cortex represents visual space using a boundary-anchored grid

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Abstract

When participants performed a visual search task, functional MRI responses in entorhinal cortex exhibited a sixfold periodic modulation by gaze-movement direction. The orientation of this modulation was determined by the shape and orientation of the bounded search space. These results indicate that human entorhinal cortex represents visual space using a boundary-anchored grid, analogous to that used by rodents to represent navigable space.

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Acknowledgements

We thank G. Aguirre for providing the eye tracking camera and J. Ryan and S. Liapis for help with data collection. This work was supported by US NIH grants EY-022350 and EY-027047 (R.A.E.) and NSF grant SBE-0541957 (R.A.E.) and Graduate Research Fellowship (J.B.J.).

Author information

Affiliations

  1. Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA

    • Joshua B. Julian
    • , Alexandra T. Keinath
    • , Giulia Frazzetta
    •  & Russell A. Epstein

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Contributions

J.B.J., A.T.K. and R.A.E. designed the study. Data collection was performed by J.B.J., A.T.K. and G.F.; J.B.J. and A.T.K. analyzed data. The manuscript was drafted by J.B.J., A.T.K. and R.A.E.

Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Joshua B. Julian or Russell A. Epstein.

Integrated Supplementary Information

Supplementary information