Acquired resistance to CD19-targeted CAR T cell therapy can occur through mutations in the CD19 gene or after insertion of a chimeric antigen receptor (CAR) into leukemia cells, resulting in the adjacent receptor being masked by the CAR.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer
Military Medical Research Open Access 08 November 2023
-
Recent findings on chimeric antigen receptor (CAR)-engineered immune cell therapy in solid tumors and hematological malignancies
Stem Cell Research & Therapy Open Access 24 September 2022
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Majzner, R. G. & Mackall, C. L. Cancer Discov. https://doi.org/10.1158/2159-8290.CD-18-0442 (2018).
Orlando, E. J. et al. Nat. Med. https://doi.org/10.1038/s41591-018-0146-z (2018).
Ruella, M. et al. Nat. Med. https://doi.org/10.1038/s41591-018-0201-9 (2018).
Sotillo, E. et al. Cancer Discov. 5, 1282–1295 (2015).
Sommermeyer, D. et al. Leukemia 31, 2191–2199 (2017).
Bagashev, A. et al. Mol. Cell. Biol. https://doi.org/10.1128/MCB.00383-18 (2018).
Fischer, J. et al. J. Immunother. 40, 187–195 (2017).
Ali, S. A. et al. Blood 128, 1688–1700 (2016).
Cho, J. H., Collins, J. J. & Wong, W. W. Cell 173, 1426–1438.e11 (2018).
Jackson, H. J., Rafiq, S. & Brentjens, R. J. Nat. Rev. Clin. Oncol. 13, 370–383 (2016).
Avanzi, M. P. et al. Cell Reports 23, 2130–2141 (2018).
Rafiq, S. et al. Nat. Biotechnol. 36, 847–856 (2018).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
R.J.B. is a cofounder of and receives royalties from Juno Therapeutics.
Rights and permissions
About this article
Cite this article
Rafiq, S., Brentjens, R.J. Tumors evading CARs—the chase is on. Nat Med 24, 1492–1493 (2018). https://doi.org/10.1038/s41591-018-0212-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41591-018-0212-6
This article is cited by
-
Efficacy of programmed cell death 1 inhibitor maintenance after chimeric antigen receptor T cells in patients with relapsed/refractory B-cell non-Hodgkin-lymphoma
Cellular Oncology (2024)
-
Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer
Military Medical Research (2023)
-
Recent findings on chimeric antigen receptor (CAR)-engineered immune cell therapy in solid tumors and hematological malignancies
Stem Cell Research & Therapy (2022)
-
Factors associated with treatment response to CD19 CAR-T therapy among a large cohort of B cell acute lymphoblastic leukemia
Cancer Immunology, Immunotherapy (2022)
-
CAR T cell therapy as a promising approach in cancer immunotherapy: challenges and opportunities
Cellular Oncology (2021)