Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

IMMUNOTHERAPY

Immunotherapy for glioblastoma: going viral

Nature Medicine volume 24, pages 1094–1096 (2018)Cite this article

Subjects

Intratumoral infusion of a nonpathogenic replication-competent recombinant polio-rhinovirus chimera for recurrent glioblastoma demonstrates safety and promising preliminary treatment responses.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Treatment of GBM with PVSRIPO results in extended survival.

References

  1. Lim, M., Xia, Y., Bettegowda, C. & Weller, M. Nat. Rev. Clin. Oncol. 15, 422–442 (2018).

    Article  CAS  Google Scholar 

  2. Desjardins, A. et al. N. Engl. J. Med. 379, 150–161 (2018).

    Article  CAS  Google Scholar 

  3. Lawler, S. E., Speranza, M.-C., Cho, C.-F. & Chiocca, E. A. JAMA Oncol. 3, 841–849 (2017).

    Article  Google Scholar 

  4. Gromeier, M., Alexander, L. & Wimmer, E. Proc. Natl Acad. Sci. USA 93, 2370–2375 (1996).

    Article  CAS  Google Scholar 

  5. Brown, M. C. et al. Sci. Transl. Med. 9, eaan4220 (2017).

    Article  Google Scholar 

  6. Trask, T. W. et al. Mol. Ther. 1, 195–203 (2000).

    Article  CAS  Google Scholar 

  7. Wheeler, L. A. et al. Neuro-oncol. 18, 1137–1145 (2016).

    Article  CAS  Google Scholar 

  8. Reardon, D. A. et al. Neuro-oncol. 19, abstr. iii21 (2017).

  9. Ribas, A. et al. Cell 170, 1109–1119.e10 (2017).

    Article  CAS  Google Scholar 

  10. Long, G. V. et al. J Clin. Oncol. 34, abstr. TPS9598 (2016).

  11. Ott, P. A. et al. Nature 547, 217–221 (2017).

    Article  CAS  Google Scholar 

  12. Keskin, D. B. et al. Cancer Res. 78, abstr. 5631 (2018).

Download references

Author information

Authors and Affiliations

  1. Department of Medical Oncology, Dana-Farber Cancer Center, Boston, MA, USA

    J. Bryan Iorgulescu, David A. Reardon & Catherine J. Wu

  2. Harvard Medical School, Boston, MA, USA

    J. Bryan Iorgulescu, David A. Reardon, E. Antonio Chiocca & Catherine J. Wu

  3. Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA

    J. Bryan Iorgulescu

  4. Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA

    David A. Reardon & Catherine J. Wu

  5. Department of Neurosurgery, Brigham and Women’s Hospital, Dana-Farber Cancer Center, Boston, MA, USA

    E. Antonio Chiocca

Authors
  1. J. Bryan Iorgulescu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David A. Reardon
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Antonio Chiocca
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Catherine J. Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Catherine J. Wu.

Ethics declarations

Competing interests

D.A.R. reports receiving honoraria, advisory, and consultant fees from Abbvie; Agenus; Bristol-Myers Squibb; Celldex; EMD Serono; Genentech/Roche; Inovio; Merck; Merck KGaA; Monteris; Novocure; Oncorus; Oxigene; Regeneron; Stemline; and Taiho Oncology, Inc. E.A.C. reports receiving consultant and advisory fees from Advantagene and Dnatrix. C.J.W. is cofounder of Neon Therapeutics and a member of its scientific advisory board. All other authors declare that they have no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Iorgulescu, J.B., Reardon, D.A., Chiocca, E.A. et al. Immunotherapy for glioblastoma: going viral. Nat Med 24, 1094–1096 (2018). https://doi.org/10.1038/s41591-018-0142-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41591-018-0142-3

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing