Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

PYROPTOSIS

Jack of all trades inhibits inflammation (in sober people)

Nature Immunology volume 21, pages 718–719 (2020)Cite this article

Subjects

Caspase-cleaved gasdermin D forms pores in cellular membranes, thus executing proinflammatory cell death by pyroptosis. Disulfiram — a drug used to treat chronic alcoholism — is now found to be an inhibitor of pore formation, which may therapeutically counteract exacerbated inflammation in sepsis and beyond.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Mechanism of GSDMD inhibition.

References

  1. Hu, J. J. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-0669-6 (2020).

  2. Kayagaki, N. et al. Nature 526, 666–671 (2015).

    Article  CAS  Google Scholar 

  3. Shi, J. et al. Nature 526, 660–665 (2015).

    Article  CAS  Google Scholar 

  4. Broz, P., Pelegrín, P. & Shao, F. Nat. Rev. Immunol. 20, 143–157 (2020).

    Article  CAS  Google Scholar 

  5. Zhou, Z. et al. Science https://doi.org/10.1126/science.aaz7548 (2020).

  6. Ridker, P. M. Circ. Res. 124, 437–450 (2019).

    Article  CAS  Google Scholar 

  7. Brydges, S. D. et al. J. Clin. Invest. 123, 4695–4705 (2013).

    Article  CAS  Google Scholar 

  8. Sollberger, G. et al. Sci. Immunol. 3, eaar6689 (2018).

    Article  Google Scholar 

  9. Ruan, J., Xia, S., Liu, X., Lieberman, J. & Wu, H. Nature 557, 62–67 (2018).

    Article  CAS  Google Scholar 

  10. Liu, Z. et al. Immunity 51, 43–49.e4 (2019).

    Article  CAS  Google Scholar 

  11. Mulvihill, E. et al. EMBO J. 37, e98321 (2018).

    Article  Google Scholar 

  12. Skrott, Z. et al. Nature 552, 194–199 (2017).

    Article  CAS  Google Scholar 

  13. Rathkey, J. K. et al. Sci. Immunol. 3, eaat2738 (2018).

    Article  Google Scholar 

  14. Liu, X. et al. Nature 535, 153–158 (2016).

    Article  CAS  Google Scholar 

  15. Buonopane, A. & Petrakis, I. L. Subst. Use Misuse 40, 2001–2020 (2009).

    Article  Google Scholar 

Download references

Acknowledgements

F.I.S. is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through the Emmy Noether Programme (SCHM 3336-1-1), SPP1923, SFB1403, TRR237 and Germany’s Excellence Strategy – EXC2151 – 390873048, as well as by the Klaus Tschira Boost Fund. E.L. is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through SPP1923, SFB1403, TRR237 and Germany’s Excellence Strategy – EXC2151 – 390873048.

Author information

Authors and Affiliations

  1. Institute of Innate Immunity, Biomedical Center, Venusberg-Campus 1, University of Bonn, Bonn, Germany

    Florian I. Schmidt & Eicke Latz

  2. German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

    Eicke Latz

  3. Department of Infectious Diseases and Immunology, UMass Medical School, Worcester, MA, USA

    Eicke Latz

Authors
  1. Florian I. Schmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eicke Latz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Florian I. Schmidt.

Ethics declarations

Competing interests

E.L. is a cofounder of IFM Therapeutics. F.I.S. is a scientific consultant of IFM Therapeutics.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schmidt, F.I., Latz, E. Jack of all trades inhibits inflammation (in sober people). Nat Immunol 21, 718–719 (2020). https://doi.org/10.1038/s41590-020-0693-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-020-0693-6

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research