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GERMINAL CENTERS

Directing traffic in the germinal center roundabout

Nature Immunology volume 21, pages 599–601 (2020)Cite this article

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B cells undergo iterative rounds of somatic hypermutation and selection for high-affinity antigen binding in the germinal center microenvironment. Two new studies provide insights into the temporal and spatial control mechanisms that act within B cells and follicular dendritic cells to jointly govern B cell differentiation and cell traffic within the GC.

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Fig. 1: Temporal and spatial control mechanisms governing B cell differentiation and cell traffic within the germinal center.

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Authors and Affiliations

  1. Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA

    Jagan R. Muppidi

  2. Division of Haematology & Immunology, Leeds Institute of Medical Research at St. James’s, University of Leeds, Leeds, UK

    Ulf Klein

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  1. Jagan R. Muppidi
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  2. Ulf Klein
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Correspondence to Ulf Klein.

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Muppidi, J.R., Klein, U. Directing traffic in the germinal center roundabout. Nat Immunol 21, 599–601 (2020). https://doi.org/10.1038/s41590-020-0690-9

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