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T CELL PROTEOMICS

TCR signaling: it’s all about the numbers

Nature Immunology volume 20, pages 1415–1416 (2019)Cite this article

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Quantitative mass spectrometry applied to T cell activation reveals key insights into signal-transduction pathways. These data identify selective alterations in the concentration of proteins in activated T cells and detail previously undescribed protein–protein interactions.

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Fig. 1: Analysis of the stoichiometry of global protein levels and protein–protein interactions by quantitative mass spectrometry in primary T cells.

References

  1. Courtney, A. H., Lo, W. L. & Weiss, A. Trends Biochem. Sci. 43, 108–123 (2018).

    Article  CAS  Google Scholar 

  2. Balagopalan, L., Kortum, R. L., Coussens, N. P., Barr, V. A. & Samelson, L. E. J. Biol. Chem. 290, 26422–26429 (2015).

    Article  CAS  Google Scholar 

  3. Araki, K., Youngblood, B. & Ahmed, R. Immunol. Rev. 235, 234–243 (2010).

    Article  CAS  Google Scholar 

  4. Howden, A.J. et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0495-x (2019).

  5. Voisinne, G. et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0489-8 (2019).

  6. Manna, A. et al. Proc. Natl Acad. Sci. USA 115, E11914–E11923 (2018).

    Article  CAS  Google Scholar 

  7. Araki, K. et al. Nature 460, 108–112 (2009).

    Article  CAS  Google Scholar 

  8. Andreotti, A. H., Joseph, R. E., Conley, J. M., Iwasa, J. & Berg, L. J. Annu. Rev. Immunol. 36, 549–578 (2018).

    Article  CAS  Google Scholar 

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  1. Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA

    James M. Conley & Leslie J. Berg

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  1. James M. Conley
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  2. Leslie J. Berg
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Correspondence to Leslie J. Berg.

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The authors declare no competing interests.

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Conley, J.M., Berg, L.J. TCR signaling: it’s all about the numbers. Nat Immunol 20, 1415–1416 (2019). https://doi.org/10.1038/s41590-019-0520-0

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