Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

TISSUE-RESIDENT T CELLS

The highs and lows of CD4+ tissue-resident T cells in lung fibrosis

Nature Immunology volume 20, pages 1416–1418 (2019)Cite this article

Subjects

Chronic exposure to fungal antigen drives the development of two subsets of CD4+ TRM cells, distinguished by high or low expression of the integrin CD103, with opposing roles in inflammation-induced lung fibrosis.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: CD103hi tissue-resident Treg cells control fibrotic responses elicited by CD103lo pathogenic CD4+ TRM cells in the lungs.

References

  1. Masopust, D., Soerens, A. G. & Tissue-Resident, T. Annu. Rev. Immunol. 37, 521–546 (2019).

    Article  CAS  Google Scholar 

  2. Ichikawa, T.et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0494-y (2019).

  3. Zundler, S. et al. Nat. Immunol. 20, 288–300 (2019).

    Article  CAS  Google Scholar 

  4. Hondowicz, B. D. et al. Immunity 44, 155–166 (2016).

    Article  CAS  Google Scholar 

  5. Iijima, N. & Iwasaki, A. Science 346, 93–98 (2014).

    Article  CAS  Google Scholar 

  6. Collins, N. et al. Nat. Commun. 7, 11514 (2016).

    Article  CAS  Google Scholar 

  7. Shinoda, K. et al. Proc. Natl Acad. Sci. USA 113, E2842–E2851 (2016).

    Article  CAS  Google Scholar 

  8. McKinstry, K. K. et al. Nat. Commun. 5, 5377 (2014).

    Article  Google Scholar 

  9. Naik, S. et al. Nature 520, 104–108 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia

    Maximilien Evrard & Laura K. Mackay

Authors
  1. Maximilien Evrard
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Laura K. Mackay
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Laura K. Mackay.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Evrard, M., Mackay, L.K. The highs and lows of CD4+ tissue-resident T cells in lung fibrosis. Nat Immunol 20, 1416–1418 (2019). https://doi.org/10.1038/s41590-019-0501-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-019-0501-3

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing