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CANCER IMMUNOLOGY

Treg cell IL-10 and IL-35 exhaust CD8+ T cells in tumors

Nature Immunology volume 20, pages 674–675 (2019)Cite this article

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Expression of the immunosuppressive cytokines IL-10 and IL-35 by tumor-infiltrating regulatory T cells drives exhaustion of intratumoral CD8+ T cells through a common pathway dependent on the transcription factor BLIMP-1.

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Fig. 1: Treg cells use IL-10 and IL-35 to drive CD8+ T cell exhaustion in tumors.

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  1. Yale University School of Medicine, Department of Immunobiology, New Haven, CT, USA

    Martina Damo & Nikhil S. Joshi

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  1. Martina Damo
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  2. Nikhil S. Joshi
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Correspondence to Nikhil S. Joshi.

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Damo, M., Joshi, N.S. Treg cell IL-10 and IL-35 exhaust CD8+ T cells in tumors. Nat Immunol 20, 674–675 (2019). https://doi.org/10.1038/s41590-019-0389-y

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