Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

RESTRICTION FACTORS

Heavy metal protease takes a tiki torch to HIV assembly

Nature Immunology volume 20, pages 668–669 (2019)Cite this article

Subjects

The plasma membrane–associated metalloprotease TRABD2A degrades the HIV Gag polyprotein and restricts virion assembly.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: HIV-1 replication is blocked at multiple stages in resting CD4+ T cells.

References

  1. Siliciano, J. D. et al. Nat. Med. 9, 727–728 (2003).

    Article  CAS  Google Scholar 

  2. Wiegand, A. et al. Proc. Natl Acad. Sci. USA 114, E3659–E3668 (2017).

    Article  CAS  Google Scholar 

  3. Baxter, A. E., O'Doherty, U. & Kaufmann, D. E. Retrovirology 15, 18 (2018).

    Article  Google Scholar 

  4. Liang, G. et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0385-2 (2019).

  5. Freed, E. O. Nat. Rev. Microbiol. 13, 484–496 (2015).

    Article  CAS  Google Scholar 

  6. Harris, R. S., Hultquist, J. F. & Evans, D. T. J. Biol. Chem. 287, 40875–40883 (2012).

    Article  CAS  Google Scholar 

  7. Zack, J. A. et al. Cell 61, 213–222 (1990).

    Article  CAS  Google Scholar 

  8. Baldauf, H.-M. et al. Nat. Med. 18, 1682–1687 (2012).

    Article  CAS  Google Scholar 

  9. Mbonye, U. & Karn, J. Annu. Rev. Virol. 4, 261–285 (2017).

    Article  CAS  Google Scholar 

  10. Lassen, K. G., Ramyar, K. X., Bailey, J. R., Zhou, Y. & Siliciano, R. F. PLoS Pathog. 2, e68 (2006).

    Article  Google Scholar 

  11. Pace, M. J. et al. PLoS Pathog. 8, e1002818 (2012).

    Article  CAS  Google Scholar 

  12. DeMaster, L. K. L. K. et al. J. Virol. 90, 2165–2179 (2015).

    Article  Google Scholar 

  13. Zhang, X. et al. Cell 149, 1565–1577 (2012).

    Article  CAS  Google Scholar 

  14. Hong, F. et al. Virology 521, 51–57 (2018).

    Article  CAS  Google Scholar 

  15. Stefanová, I., Dorfman, J. R. & Germain, R. N. Nature 420, 429–434 (2002).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Transfusion Medicine and Therapeutic Pathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Una O’Doherty

  2. Virus–Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA

    Eric O. Freed

Authors
  1. Una O’Doherty
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eric O. Freed
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Una O’Doherty or Eric O. Freed.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

O’Doherty, U., Freed, E.O. Heavy metal protease takes a tiki torch to HIV assembly. Nat Immunol 20, 668–669 (2019). https://doi.org/10.1038/s41590-019-0387-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-019-0387-0

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing