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GENE REGULATION

Old dog PU.1 reveals new tricks

Nature Immunology volume 20, pages 520–522 (2019)Cite this article

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The transcription factor PU.1 is not needed for the maintenance of neutrophil identity but is essential for the prevention of excessive tissue damage due to a prolonged immune response. PU.1 restrains the activation of neutrophils by antagonizing the AP-1 transcription factor JunB.

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Fig. 1: PU.1 represses transcription in neutrophils through chromatin modifications that deny access to AP-1 transcription factors.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Indiana University School of Medicine, South Bend, IN, USA

    Richard Dahl

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  1. Richard Dahl
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Correspondence to Richard Dahl.

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The author declares no competing interests.

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Dahl, R. Old dog PU.1 reveals new tricks. Nat Immunol 20, 520–522 (2019). https://doi.org/10.1038/s41590-019-0380-7

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