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FLU VACCINES

Fighting influenza through hemagglutinin diversity

A multivalent vaccine that presents diverse influenza virus subtype H1 hemagglutinins on its surface induces broadly neutralizing antibodies in an animal model by displaying conserved epitopes at higher density than strain-specific epitopes.

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Fig. 1: Strategies for the induction of antibody responses to immunosubdominant conserved epitopes on influenza virus HA.

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Correspondence to Florian Krammer.

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Competing interests

The Icahn School of Medicine at Mount Sinai has filed patent applications for vaccines against influenza virus that name F.K. as an inventor. The Krammer laboratory currently receives funding from the Bill and Melinda Gates Foundation, the US Department of Defense, PATH, the US National Institute of Allergy and Infectious Diseases and GlaxoSmithKline for research on vaccines against influenza virus.

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Krammer, F. Fighting influenza through hemagglutinin diversity. Nat Immunol 20, 246–247 (2019). https://doi.org/10.1038/s41590-019-0317-1

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