A multivalent vaccine that presents diverse influenza virus subtype H1 hemagglutinins on its surface induces broadly neutralizing antibodies in an animal model by displaying conserved epitopes at higher density than strain-specific epitopes.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Kanekiyo, M. et al. Nat. Immunol. https://doi.org/10.1038/s41559-018-0305-x (2019).
Krammer, F. Expert Rev. Vaccines 16, 503–513 (2017).
Pica, N. et al. Proc. Natl Acad. Sci. USA 109, 2573–2578 (2012).
Andrews, S. F. et al. Sci. Transl. Med. 7, 316ra192 (2015).
Anderson, A. M., Baranowska-Hustad, M., Braathen, R., Grodeland, G. & Bogen, B. J. Immunol. 200, 2057–2066 (2018).
Kirkpatrick, E., Qiu, X., Wilson, P. C., Bahl, J. & Krammer, F. Sci. Rep. 8, 10432 (2018).
Broecker, F. et al. J. Virol. 92, e01100-18 (2018).
Liu, S. T. H. et al. J. Clin. Invest. 128, 4992–4996 (2018).
Sun, W. et al. J. Virol. 93, e01673-18 (2018).
Garretson, T. A., Petrie, J. G., Martin, E. T., Monto, A. S. & Hensley, S. E. Vaccine 36, 4095–4101 (2018).
Woodruff, M. C., Kim, E. H., Luo, W. & Pulendran, B. Cell Rep. 25, 321–327 (2018).
Ekiert, D. C. et al. Nature 489, 526–532 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The Icahn School of Medicine at Mount Sinai has filed patent applications for vaccines against influenza virus that name F.K. as an inventor. The Krammer laboratory currently receives funding from the Bill and Melinda Gates Foundation, the US Department of Defense, PATH, the US National Institute of Allergy and Infectious Diseases and GlaxoSmithKline for research on vaccines against influenza virus.
Rights and permissions
About this article
Cite this article
Krammer, F. Fighting influenza through hemagglutinin diversity. Nat Immunol 20, 246–247 (2019). https://doi.org/10.1038/s41590-019-0317-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-019-0317-1