Acidic microenvironments induced by highly glycolytic tumor cells promote the noninflammatory polarization of tumor-associated macrophages, which leads to immunoevasion.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Walenta, S. et al. Cancer Res. 60, 916–921 (2000).
Bohn et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0226-8 (2018).
Chen, D. S. & Mellman, I. Nature 541, 321–330 (2017).
Seliger, B. et al. Eur. J. Immunol. 28, 122–133 (1998).
Kitamura, H., Onodera, Y., Murakami, S., Suzuki, T. & Motohashi, H. Oncogene 36, 6315–6324 (2017).
DeBerardinis, R. J. & Chandel, N. S. Sci. Adv. 2, e1600200 (2016).
Hirschhaeuser, F., Sattler, U. G. & Mueller-Klieser, W. Cancer Res. 71, 6921–6925 (2011).
Colegio, O. R. et al. Nature 513, 559–563 (2014).
Chang, C. H. et al. Cell 162, 1229–1241 (2015).
Buck, M. D., Sowell, R. T., Kaech, S. M. & Pearce, E. L. Cell 169, 570–586 (2017).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests
Rights and permissions
About this article
Cite this article
Sekine, H., Yamamoto, M. & Motohashi, H. Tumors sweeten macrophages with acids. Nat Immunol 19, 1281–1283 (2018). https://doi.org/10.1038/s41590-018-0258-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-018-0258-0
This article is cited by
-
Accumulation of hypoxia imaging probe “18F-FMISO” in macrophages depends on macrophage polarization in addition to hypoxic state
Annals of Nuclear Medicine (2019)