Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

DENGUE VIRUS

Flat-lying antibody prevents disease enhancement

An antibody to dengue virus that lies flat on its target, neutralizes the virus and also prevents antibody-dependent enhancement of infection is now identified.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Proposed ways whereby IgG in complex with the class III DENV2 warm structure5 would either allow or disallow binding to the Fc receptor.

References

  1. Halstead, S. B. Adv. Virus Res. 60, 421–467 (2003).

    Article  CAS  Google Scholar 

  2. Renner, M. F. et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0227-7 (2018).

    Article  Google Scholar 

  3. Radaev, S. & Sun, P. Mol. Immunol. 38, 1073–1083 (2002).

    Article  CAS  Google Scholar 

  4. Zhang, X. et al. Proc. Natl. Acad. Sci. USA 110, 6795–6799 (2013).

    Article  CAS  Google Scholar 

  5. Fibriansah, G. et al. J. Virol. 87, 7585–7592 (2013).

    Article  CAS  Google Scholar 

  6. Zhang, X. et al. Nat. Struct. Mol. Biol. 20, 105–110 (2013).

    Article  Google Scholar 

  7. Kostyuchenko, V. A., Chew, P. L., Ng, T. S. & Lok, S. M. J. Virol. 88, 477–482 (2014).

    Article  Google Scholar 

  8. Radaev, S., Motyka, S., Fridman, W. H., Sautes-Fridman, C. & Sun, P. D. J. Biol. Chem. 276, 16469–16477 (2001).

    Article  CAS  Google Scholar 

  9. Saphire, E. O. et al. Science 293, 1155–1159 (2001).

    Article  CAS  Google Scholar 

  10. Sondermann, P., Huber, R., Oosthuizen, V. & Jacob, U. Nature 406, 267–273 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shee-Mei Lok.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lok, SM. Flat-lying antibody prevents disease enhancement. Nat Immunol 19, 1150–1152 (2018). https://doi.org/10.1038/s41590-018-0239-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-018-0239-3

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing