Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

B CELL METABOLISM

B cells race the clock to get a second wind

Co-stimulatory second signals delivered through TLRs or CD40 rescue antigen-stimulated B cells from metabolic dysfunction and apoptosis. This identifies a critical time-limited window during which B cells integrate sequential signals to successfully initiate humoral immunity.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Spatiotemporal context of B cell metabolic reprogramming in the antibody response.

Marina Corral Spence/Springer Nature

References

  1. Boothby, M. & Rickert, R. C. Immunity 46, 743–755 (2017).

    Article  CAS  Google Scholar 

  2. Akkaya, M. et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0156-5 (2018).

    Article  CAS  Google Scholar 

  3. Tangye, S. G. Trends Immunol. 32, 595–602 (2011).

    Article  CAS  Google Scholar 

  4. Sandoval, H., Kodali, S. & Wang, J. Mitochondrion 41, 58–65 (2018).

    Article  CAS  Google Scholar 

  5. Tangye, S. G. & Tarlinton, D. M. Eur. J. Immunol. 39, 2065–2075 (2009).

    Article  CAS  Google Scholar 

  6. Tangye, S. G., Brink, R., Goodnow, C. C. & Phan, T. G. Cell 162, 926–926 (2015).

    Article  CAS  Google Scholar 

  7. Nutt, S. L., Hodgkin, P. D., Tarlinton, D. M. & Corcoran, L. M. Nat. Rev. Immunol. 15, 160–171 (2015).

    Article  CAS  Google Scholar 

  8. Tellier, J. et al. Nat. Immunol. 17, 323–330 (2016).

    Article  CAS  Google Scholar 

  9. Caro-Maldonado, A. et al. J. Immunol. 192, 3626–3636 (2014).

    Article  CAS  Google Scholar 

  10. Pearson, T. S., Akman, C., Hinton, V. J., Engelstad, K. & De Vivo, D. C. Curr. Neurol. Neurosci. Rep. 13, 342 (2013).

    Article  Google Scholar 

  11. Walker, M. A., Volpi, S., Sims, K. B., Walter, J. E. & Traggiai, E. J. Immunol. Res. 2014, 164309 (2014).

    Article  Google Scholar 

  12. Jung, S., Gámez-Díaz, L., Proietti, M. & Grimbacher, B. Front. Immunol. https://doi.org/10.3389/fimmu.2018.00966 (2018).

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Tri Giang Phan or Stuart G. Tangye.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Phan, T.G., Tangye, S.G. B cells race the clock to get a second wind. Nat Immunol 19, 791–793 (2018). https://doi.org/10.1038/s41590-018-0166-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-018-0166-3

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing