Systemic exposure to dietary and microbial components induces long-lasting epigenetic and metabolic changes in myeloid precursor cells, which results in enhanced proinflammatory and anti-microbial responses of mononuclear phagocytes after challenge with related or unrelated stimuli.
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References
Bekkering, S. et al. Cell 172, 135–146 (2018).
Christ, A. et al. Cell 172, 162–175 (2018).
Kaufmann, E. et al. Cell 172, 176–190 (2018).
Mitroulis, I. et al. Cell 172, 147–161 (2018).
Netea, M. G. et al. Science 352, aaf1098 (2016).
Arts, R. J. W. et al. Cell Host Microbe 23, 89–100 (2018).
Jiang, Y. et al. Biochem. Biophys. Res. Commun. 425, 121–126 (2012).
Freigang, S. et al. Eur. J. Immunol. 41, 2040–2051 (2011).
Duewell, P. et al. Nature 464, 1357–1361 (2010).
Bekkering, S. et al. Arterioscler. Thromb. Vasc. Biol. 34, 1731–1738 (2014).
Arts, R. J. et al. Cell Metab. 24, 807–819 (2016).
Huypens, P. et al. Nat. Genet. 48, 497–499 (2016).
Ng, S. F. et al. Nature 467, 963–966 (2010).
Pietras, E. M. et al. Nat. Cell Biol. 18, 607–618 (2016).
Geiger, H., de Haan, G. & Florian, M. C. Nat. Rev. Immunol. 13, 376–389 (2013).
Manzel, A. et al. Curr. Allergy Asthma Rep. 14, 404 (2014).
Hackam, D. G., Mamdani, M., Li, P. & Redelmeier, D. A. Lancet 367, 413–418 (2006).
van den Hoek, H. L., Bos, W. J., de Boer, A. & van de Garde, E. M. Br. Med. J. 343, d7281 (2011).
Sylvester, R. J. J. Urol. 168, 1964–1970 (2002).
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Kopf, M., Nielsen, P.J. Training myeloid precursors with fungi, bacteria and chips. Nat Immunol 19, 320–322 (2018). https://doi.org/10.1038/s41590-018-0073-7
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DOI: https://doi.org/10.1038/s41590-018-0073-7
