Phenotypic screening is an engine of discovery for bioactive small molecules and can unravel novel mechanisms and pathways controlling cellular physiology. A recent study reveals the CPSF complex as a pharmacologically tractable target of JTE-607 and context-specific cancer dependency.
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Erb, M.A. Processing for destruction. Nat Chem Biol 16, 3–4 (2020). https://doi.org/10.1038/s41589-019-0428-x
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DOI: https://doi.org/10.1038/s41589-019-0428-x
