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PHASE SEPARATION

A signal to condense

Nature Chemical Biology volume 15, pages 5–6 (2019)Cite this article

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Phase separation underlies the formation of cellular membrane-less organelles. A new report identifies deacetylation at lysine residues of intrinsically disordered protein regions to drive liquid droplet formation in vitro and stress granule maturation inside cells.

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Fig. 1: Model of phase separation control through lysine side chain acetylation in mammalian cells.

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Authors and Affiliations

  1. Department of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Diseases Research (CIID), University of Heidelberg, Heidelberg, Germany

    Alessia Ruggieri

  2. Division of Biochemistry, Center for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

    Georg Stoecklin

  3. Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany

    Georg Stoecklin

Authors
  1. Alessia Ruggieri
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  2. Georg Stoecklin
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Correspondence to Georg Stoecklin.

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The authors declare no competing interests.

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Ruggieri, A., Stoecklin, G. A signal to condense. Nat Chem Biol 15, 5–6 (2019). https://doi.org/10.1038/s41589-018-0179-0

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