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GENE REGULATION

Pioneering the chromatin landscape

New genomic analyses indicate that pioneer transcription factors can sample a diverse repertoire of common binding sites among different cell types and become enriched where they cooperate with other factors specific to each cell. Pioneer-factor binding is mechanistically separate from, and is necessary for, subsequent phenomena of chromatin opening and epigenetic memory in vivo.

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Author information

Affiliations

  1. Institute for Regenerative Medicine, Epigenetics Program, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania Smilow Center for Translational Research, Philadelphia, PA, USA

    • Kenneth S. Zaret

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Kenneth S. Zaret.