News & Views | Published:

ENHANCER EPIGENETICS

Is H3K4me1 at enhancers correlative or causative?

Nature Geneticsvolume 50pages45 (2018) | Download Citation

H3K4me1 is enriched at active and primed enhancers. However, whether H3K4me1 controls or simply correlates with enhancer activity and function has remained unclear. Several recent reports, including two in Nature Genetics, provide major mechanistic and functional insights into the role of H3K4me1 at enhancers.

  • Subscribe to Nature Genetics for full access:

    $59

    Subscribe

Additional access options:

Already a subscriber?  Log in  now or  Register  for online access.

References

  1. 1.

    ENCODE Project Consortium. Nature 489, 57–74 (2012).

  2. 2.

    Smith, E. & Shilatifard, A. Nat. Struct. Mol. Biol. 21, 210–219 (2014).

  3. 3.

    Creyghton, M. P. et al. Proc. Natl. Acad. Sci. USA 107, 21931–21936 (2010).

  4. 4.

    Heintzman, N. D. et al. Nature 459, 108–112 (2009).

  5. 5.

    Rada-Iglesias, A. et al. Nature 470, 279–283 (2011).

  6. 6.

    Dorighi, K. M. et al. Mol. Cell 66, 568–576 (2017).

  7. 7.

    Local, A. et al. Nat. Genet. https://doi.org/10.1038/s41588-017-0015-6 (2017).

  8. 8.

    Rickels, R. et al. Nat. Genet. 49, 1647–1653 (2017).

  9. 9.

    Wysocka, J. et al. Cell 121, 859–872 (2005).

  10. 10.

    Alver, B. H. et al. Nat. Commun. 8, 14648 (2017).

  11. 11.

    Herz, H.-M. et al. Genes Dev. 26, 2604–2620 (2012).

  12. 12.

    Lagha, M., Bothma, J. P. & Levine, M. Trends Genet. 28, 409–416 (2012).

  13. 13.

    Wang, A. et al. Cell Stem Cell 16, 386–399 (2015).

  14. 14.

    Stadler, M. B. et al. Nature 480, 490–495 (2011).

  15. 15.

    Ooi, S. K. T. et al. Nature 448, 714–717 (2007).

Download references

Author information

Affiliations

  1. Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany

    • Alvaro Rada-Iglesias
  2. Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases, Cologne, Germany

    • Alvaro Rada-Iglesias

Authors

  1. Search for Alvaro Rada-Iglesias in:

Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Alvaro Rada-Iglesias.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/s41588-017-0018-3

Rights and permissions

To obtain permission to re-use content from this article visit RightsLink.