A new study illustrates the power of the human induced pluripotent stem cell (hiPSC) platform by studying hiPSC-derived sensory neurons from 107 individuals. In addition to identifying thousands of quantitative trait loci influencing gene expression, chromatin accessibility and RNA splicing, the work highlights several underappreciated challenges in the hiPSC field.
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References
Schwartzentruber, J. et al. Nat. Genet. https://doi.org/10.1038/s41588-017-0005-8 (2017).
GTEx Consortium. Nature 550, 204–213 (2017).
Fromer, M. et al. Nat. Neurosci. 19, 1442–1453 (2016).
D’Antonio, M. et al. Stem Cell Rep. 8, 1101–1111 (2017).
Carcamo-Orive, I. et al. Cell Stem Cell 20, 518–532 (2017).
DeBoever, C. et al. Cell Stem Cell 20, 533–546 (2017).
Panopoulos, A. D. et al. Cell Stem Cell 20, 505–517 (2017).
Warren, C. R. et al. Cell Stem Cell 20, 547–557 (2017).
Pashos, E. E. et al. Cell Stem Cell 20, 558–570 (2017).
Panopoulos, A. D. et al. Stem Cell Rep. 8, 1086–1100 (2017).
Banovich, N.E. et al. Preprint at bioRxiv https://doi.org/10.1101/091660 (2016).
Rouhani, F. et al. PLoS Genet. 10, e1004432 (2014).
Kilpinen, H. et al. Nature 546, 370–375 (2017).
Hoffman, G.E. et al. Preprint at bioRxiv https://doi.org/10.1101/185546 (2017).
Germain, P. L. & Testa, G. Stem Cell Rep. 8, 1784–1796 (2017).
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Hoffman, G.E., Brennand, K.J. Mapping regulatory variants in hiPSC models. Nat Genet 50, 1–2 (2018). https://doi.org/10.1038/s41588-017-0017-4
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DOI: https://doi.org/10.1038/s41588-017-0017-4
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