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RNA THERAPEUTICS

Doubling down on siRNAs in the brain

Nature Biotechnology volume 37, pages 865–866 (2019)Cite this article

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Divalent siRNAs induce widespread gene silencing in the brains of mice and non-human primates.

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Fig. 1: Chemical and viral-based methods for inducing gene silencing.

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Authors and Affiliations

  1. The Raymond G. Perelman Center for Cellular and Molecular Therapeutics, the Children’s Hospital of Philadelphia, and the Department of Pathology and Laboratory Medicine, The University of Pennsylvania, Philadelphia, PA, USA

    Beverly L. Davidson

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  1. Beverly L. Davidson
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Correspondence to Beverly L. Davidson.

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Competing interests

B.L.D. is a founder of Spark Therapeutics, Inc and Talee Bio, and is on the scientific advisory boards of Homology Medicines, Prevail Therapeutics, Sarepta Therapeutics and Panorama Medicines.

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Davidson, B.L. Doubling down on siRNAs in the brain. Nat Biotechnol 37, 865–866 (2019). https://doi.org/10.1038/s41587-019-0204-1

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