In vivo studies indicate that cytosine but not adenine base editors induce elevated levels of genome-wide off-target substitutions.
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References
Rees, H. A. & Liu, D. R. Nat. Rev. Genet. 19, 770–788 (2018).
Zuo, E. et al. Science https://doi.org/10.1126/science.aav9973 (2019).
Jin, S. et al. Science https://doi.org/10.1126/science.aaw7166 (2019).
Kim, D., Kim, D. E., Lee, G., Cho, S. I. & Kim, J. S. Nat. Biotechnol. https://doi.org/10.1038/s41587-019-0050-1 (2019).
Haapaniemi, E., Botla, S., Persson, J., Schmierer, B. & Taipale, J. Nat. Med. 24, 927–930 (2018).
Kosicki, M., Tomberg, K. & Bradley, A. Nat. Biotechnol. 36, 765–771 (2018).
Kim, D. et al. Nat. Biotechnol. 35, 475–480 (2017).
Yang, B., Li, X., Lei, L. & Chen, J. J. Genet. Genomics 44, 423–437 (2017).
Kim, Y. B. et al. Nat. Biotechnol. 35, 371–376 (2017).
Wang, X. et al. Nat. Biotechnol. 36, 946–949 (2018).
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Chen, J., Yang, B. & Yang, L. To BE or not to BE, that is the question. Nat Biotechnol 37, 520–522 (2019). https://doi.org/10.1038/s41587-019-0119-x
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DOI: https://doi.org/10.1038/s41587-019-0119-x
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