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Evolution of CAR T-cell immunotherapy in terms of patenting activity

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An analysis of published patent applications in chimeric antigen receptor (CAR) T-cell immunotherapy allows insight into the development of this emerging technology.

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Fig. 1
Fig. 2: Geographical analysis of CAR T-cell patenting activity.
Fig. 3
Fig. 4: Patenting evolution of the top five CAR T-cell applicants.
Fig. 5: Network node map of CAR T-cell applicants.
Fig. 6: CAR T-cell patent value analysis.

Change history

  • 09 April 2019

    In the version of this article initially published online, the abstract read “dedvelopment” instead of “development” as a result of a publisher error. The error has been corrected in the print, PDF and HTML versions of this article.

References

  1. Kolata, G. New gene-therapy treatments will carry whopping price tags. The New York Times https://www.nytimes.com/2017/09/11/health/cost-gene-therapy-drugs.html (11 September 2017).

  2. Grady, D. Companies rush to develop ‘utterly transformative’ gene therapies. The New York Times https://www.nytimes.com/2017/07/23/health/gene-therapy-cancer.html (23 July 2017).

  3. Sadelain, M. & Rivière, I. CAR T cells in cancer therapy (poster). Nat. Rev. Drug Disc. (December 2017).

  4. Golstein, P. & Griffiths, G. M. Nat. Rev. Immunol. 18, 527–535 (2018).

    Article  CAS  Google Scholar 

  5. Mullard, A. Nat. Rev. Drug Discov. 14, 301 (2015).

    Google Scholar 

  6. Morrison, C. Nat. Biotechnol. 33, 571–572 (2015).

    Article  CAS  Google Scholar 

  7. Dolgin, E. Nat. Biotechnol. 35, 891–892 (2017).

    Article  CAS  Google Scholar 

  8. Trippe, A. Guidelines for Preparing Patent Landscape Reports (World Intellectual Property Organization, 2015).

  9. Zuniga, P. et al. OECD Patent Statistics Manual (OECD, 2009).

  10. European IPR Helpdesk. E-IPR fact sheet: automatic patent analysis. https://www.iprhelpdesk.eu/sites/default/files/newsdocuments/Fact-Sheet-Automatic-Patent-Analysis.pdf (2013).

  11. Jürgens, B. & Herrero-Solana, V. J. Intell. Stud. Bus. 7, 17–26 (2017).

    Google Scholar 

  12. Dara, A. & Sangamwar, A. T. PLoS One 9, e103847 (2014).

    Article  Google Scholar 

  13. Pan, C. L. & Chen, F. C. Hum. Vaccin. Immunother. 13, 2583–2593 (2017).

    Article  Google Scholar 

  14. Anaya, M., Perez-Santos, M. & Muñoz-Rojas, J. Intl. J. Cancer Biol. Clin. Oncol. 1, 14–18 (2017).

    Google Scholar 

  15. Anonymous. Nat. Biotechnol. 35, 215 (2017).

    Article  Google Scholar 

  16. Bouchie, A., Allison, M., Webb, S. & DeFrancesco, L. Nat. Biotechnol. 32, 229–238 (2014).

    Article  CAS  Google Scholar 

  17. Bouchie, A. & DeFrancesco, L. Nat. Biotechnol. 33, 247–255 (2015).

    Article  CAS  Google Scholar 

  18. Morrison, C. Nat. Biotechnol. 36, 131–136 (2018).

  19. Yeager, A.J. CAR-T in the courts. Genetic Engineering News (11 September 2017).

Download references

Acknowledgements

This article is based on a study that was commissioned by the European Patent Office with the aim of demonstrating to readers outside the disciplines of patent analysis and CAR T-cell immunotherapy how patent information can be used to gain insight and competitive advantages about a specific technological field. The authors thank F. Aslund, P. Bumb and D. Manu from the European Patent Office for their support in the classification identification process and assistance for fine-tuning the search strategy. The opinions expressed in this article are those of the authors and not necessarily those of their employers.

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Correspondence to Nigel S. Clarke.

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Jürgens, B., Clarke, N.S. Evolution of CAR T-cell immunotherapy in terms of patenting activity. Nat Biotechnol 37, 370–375 (2019). https://doi.org/10.1038/s41587-019-0083-5

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