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Data availability
The data supporting the findings of this study are available within the paper or from the corresponding author upon reasonable request.
References
Vandewauw, I. et al. A TRP channel trio mediates acute noxious heat sensing. Nature 555, 662–666 (2018).
Vilar, B., Tan, C.-H. & McNaughton, P. A. Heat detection by the TRPM2 ion channel. Nature https://doi.org/10.1038/s41586-020-2510-7 (2020).
Tan, C. H. & McNaughton, P. A. The TRPM2 ion channel is required for sensitivity to warmth. Nature 536, 460–463 (2016).
Bautista, D. M. et al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124, 1269–1282 (2006).
Caterina, M. J. et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288, 306–313 (2000).
Vriens, J. et al. TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron 70, 482–494 (2011).
Song, K. et al. The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia. Science 353, 1393–1398 (2016).
Acknowledgements
We thank all members of the Laboratories of Ion Channel Research and Experimental Gynecology and Obstetrics for comments and discussion. This work was supported by grants from KU Leuven Research Council (C1-TRPLe to T.V), the Research Foundation-Flanders (FWO G.084515N to J.V. and T.V.), the Queen Elisabeth Medical Foundation for Neurosciences (to T.V.), the Belgian Foundation Against Cancer (to J.V. and T.V.) and by the Planckaert-De Waele fund (to J.V.).
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M.M. and I.V. performed cellular calcium imaging experiments. M.M., I.V. and T.V. analysed the data. J.V. and T.V. supervised the project. T.V. wrote the manuscript with input from all authors. The other authors of the original paper1 were not involved in the experiments described in this manuscript, but agree with the conclusions.
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Mulier, M., Vandewauw, I., Vriens, J. et al. Reply to: Heat detection by the TRPM2 ion channel. Nature 584, E13–E15 (2020). https://doi.org/10.1038/s41586-020-2511-6
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DOI: https://doi.org/10.1038/s41586-020-2511-6
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