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Reply to: Heat detection by the TRPM2 ion channel

The Original Article was published on 12 August 2020

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Fig. 1: TRPV1- and TRPM3-independent responses to a 45 °C heat stimulus are not inhibited by the TRPM2 antagonist 2-APB.
Fig. 2: High-threshold 2-APB-sensitive heat responses in TKO sensory neurons.

Data availability

The data supporting the findings of this study are available within the paper or from the corresponding author upon reasonable request.

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Acknowledgements

We thank all members of the Laboratories of Ion Channel Research and Experimental Gynecology and Obstetrics for comments and discussion. This work was supported by grants from KU Leuven Research Council (C1-TRPLe to T.V), the Research Foundation-Flanders (FWO G.084515N to J.V. and T.V.), the Queen Elisabeth Medical Foundation for Neurosciences (to T.V.), the Belgian Foundation Against Cancer (to J.V. and T.V.) and by the Planckaert-De Waele fund (to J.V.).

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M.M. and I.V. performed cellular calcium imaging experiments. M.M., I.V. and T.V. analysed the data. J.V. and T.V. supervised the project. T.V. wrote the manuscript with input from all authors. The other authors of the original paper1 were not involved in the experiments described in this manuscript, but agree with the conclusions.

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Correspondence to Joris Vriens or Thomas Voets.

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Mulier, M., Vandewauw, I., Vriens, J. et al. Reply to: Heat detection by the TRPM2 ion channel. Nature 584, E13–E15 (2020). https://doi.org/10.1038/s41586-020-2511-6

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  • DOI: https://doi.org/10.1038/s41586-020-2511-6

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