Immunogenomic analysis of advanced prostate cancer has identified immunological alterations associated with defective mismatch repair (dMMR) that could inform immunotherapy strategies. Overall, dMMR status was confirmed in 8.1% of patients and was associated with poor overall survival; dMMR tumours with high microsatellite instability (MSI) had increased mutational load, T cell infiltration, and PD-L1 expression. Interestingly, dMMR mutational signatures positively correlated with MSI and expression of immune-associated genes, including PDL1 and PDL2.
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Nava Rodrigues, D. et al. Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer. J. Clin. Invest. https://doi.org/10.1172/JCI121924 (2018)
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Bradley, C.A. Immunogenomic landscape of dMMR tumours. Nat Rev Urol 15, 726 (2018). https://doi.org/10.1038/s41585-018-0095-9
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DOI: https://doi.org/10.1038/s41585-018-0095-9