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TESTICULAR CANCER

Familial TGCT: polygenic aetiology advanced

Nature Reviews Urology volume 15, pages 665–666 (2018)Cite this article

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A polygenic risk score (PRS) analysis reported that familial testicular germ cell tumours (TGCTs) were significantly enriched for TGCT risk alleles and that ≥84% were attributable to polygenic enrichment, supporting the polygenic aetiological basis of familial TGCT. Clinical application will first require improved TGCT screening and early detection tools.

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Fig. 1: Polygenic risk score distribution in sporadic and familial TGCT.

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Acknowledgements

The authors are deeply indebted to the members of families prone to testicular germ cell tumour for their invaluable contributions to our clinical research, which could not have been done without their selfless cooperation.

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Authors and Affiliations

  1. Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA

    Mark H. Greene

  2. Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA

    Ruth M. Pfeiffer

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  1. Mark H. Greene
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  2. Ruth M. Pfeiffer
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Correspondence to Mark H. Greene.

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The authors declare no competing interests.

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Testicular Cancer Consortium: http://www.tecac.org

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Greene, M.H., Pfeiffer, R.M. Familial TGCT: polygenic aetiology advanced. Nat Rev Urol 15, 665–666 (2018). https://doi.org/10.1038/s41585-018-0093-y

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