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PROSTATE CANCER

Enzalutamide treatment for the whole spectrum of CRPC

The FDA recently expanded the indication for enzalutamide for the treatment of all men with metastatic and nonmetastatic castration-resistant prostate cancer on the basis of the PROSPER trial. Now that both disease states can have the same treatment, the need to thoroughly identify metastatic lesions is questioned.

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Fig. 1: Current and potential metastatic work-ups for men with castration-resistant prostate cancer.

References

  1. Hussain, M. et al. Enzalutamide in men with nonmetastatic, castration-resistant prostate cancer. N. Engl. J. Med. 378, 2465–2474 (2018).

    Article  CAS  Google Scholar 

  2. Smith, M. R. et al. Apalutamide treatment and metastasis-free survival in prostate cancer. N. Engl. J. Med. 378, 1408–1418 (2018).

    Article  CAS  Google Scholar 

  3. Tran, C. et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 324, 787–790 (2009).

    Article  CAS  Google Scholar 

  4. Beer, T. M. & Tombal, B. Enzalutamide in metastatic prostate cancer before chemotherapy. N. Engl. J. Med. 371, 1755–1756 (2014).

    Article  Google Scholar 

  5. Scher, H. I. et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. N. Engl. J. Med. 367, 1187–1197 (2012).

    Article  CAS  Google Scholar 

  6. Chandler, R. & de Bono, J. Second-generation antiandrogens in nonmetastatic CRPC. Nat. Rev. Urol. 15, 342–344 (2018).

    Article  CAS  Google Scholar 

  7. Gomella, L. G. Prostate cancer CRPC stage M0 and M1: do we need stage M0.5? Can. J. Urol. 25, 9220 (2018).

    PubMed  Google Scholar 

  8. Li, R. et al. The use of PET/CT in prostate cancer. Prostate Cancer Prostat. Dis. 21, 4–21 (2018).

    Article  Google Scholar 

  9. US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/record/NCT02319837 (2018).

  10. Whitney, C. et al. Impact of age, comorbidity, and PSA doubling time on long-term competing risks for mortality among men with non-metastatic castration-resistant prostate cancer. Prostate Cancer Prostatic Dis. (in the press).

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Correspondence to Stephen Freedland.

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S.F. is a consultant to Pfizer, Astellas, and Janssen. H.Z. declares no competing interests.

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Zhao, H., Freedland, S. Enzalutamide treatment for the whole spectrum of CRPC. Nat Rev Urol 15, 663–665 (2018). https://doi.org/10.1038/s41585-018-0090-1

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