Distinct patterns of gut microbiome dysbiosis correlated with disease activity in a study of 61 female patients with systemic lupus erythematosus (SLE). The results of faecal 16S rRNA analysis were confirmed in two independent SLE cohorts and revealed a fivefold increase in the amount of Ruminococcus gnavus in patients with SLE compared with healthy individuals. Expanded populations of R. gnavus were particularly prevalent in patients with lupus nephritis; individuals with active nephritis also had high serum concentrations of antibodies against cell wall lipoglycans from certain strains of R. gnavus.
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Azzouz, D. et al. Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal. Ann. Rheum. Dis. https://doi.org/10.1136/annrheumdis-2018-214856 (2019)
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Collison, J. Gut microbiota linked to kidney disease in SLE. Nat Rev Rheumatol 15, 188 (2019). https://doi.org/10.1038/s41584-019-0196-8
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DOI: https://doi.org/10.1038/s41584-019-0196-8
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